A Soft and Absorbable Temporary Epicardial Pacing Wire

Hang, Chen1,2,3; Ding, Li1,4; Cheng, Shiyu2; Dong, Ruihua2,3; Qi, Jie1,2,3; Liu, Xiaoyan1,2,3; Liu, Qian2,3; Zhang, Yan4; Jiang, Xingyu1,2,3

2021-07-01

10.1002/adma.202101447

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Existing temporary epicardial pacing wires (TPWs) are rigid and non-absorbable, such that they can cause severe complications after cardiac surgery. Here, a soft and absorbable temporary epicardial pacing wire (saTPW) for effectively correcting abnormal heart rates in a rabbit model, such as bradycardia and ventricular premature beat, is developed. The saTPW exhibits excellent conductivity, flexibility, cycling stability (>100 000 cycles), and less inflammatory response during two-month subcutaneous implantation in a rat model. The saTPW which consists of poly(l-lactide-co-epsilon-caprolactone) and liquid metal, can degrade about 13% (mass loss) in the rats over a two-month subcutaneous implantation. It can be absorbed over time in the body. The cytocompatibility and absorbability avoid secondary injuries caused by remaining wires which are permanently left in the body. The saTPW will provide a great platform for diagnosis and treatments in cardiovascular diseases by delivering the physiological signal and applying electrical stimulation for therapy.

bioelectronics liquid metals poly(L-lactide-co-epsilon-caprolactone) temporary epicardial pacing wire

SCI ; EI

英语

NI论文

第一 ; 通讯

National Key R&D Program of China["2018YFA0902600","2017YFA0205901"] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; National Natural Science Foundation of China[21535001,81730051,21761142006,51973045] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","XDA16020902"] ; Beijing Science and Technology Plan Project[Z191100007619053] ; Postgraduate Innovation Foundation of Peking Union Medical College[2019-1002-28] ; Teaching Reform Foundation of Postgraduate Education in Peking Union Medical College[10023201900202] ; CAMS Innovation Fund for Medical Sciences[2020-I2M-CT-B-058]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000677212900001

WILEY-V C H VERLAG GMBH

20213010692697

Cardiology ; Cardiovascular surgery ; Diagnosis ; Disease control ; Diseases

Medicine and Pharmacology:461.6 ; Metal Forming:535.2

MATERIALS SCIENCE

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Key Lab Nanosyst & Hierarch Fabricat, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

Hang, Chen,Ding, Li,Cheng, Shiyu,et al. A Soft and Absorbable Temporary Epicardial Pacing Wire[J]. ADVANCED MATERIALS,2021,33.

Hang, Chen.,Ding, Li.,Cheng, Shiyu.,Dong, Ruihua.,Qi, Jie.,...&Jiang, Xingyu.(2021).A Soft and Absorbable Temporary Epicardial Pacing Wire.ADVANCED MATERIALS,33.

Hang, Chen,et al."A Soft and Absorbable Temporary Epicardial Pacing Wire".ADVANCED MATERIALS 33(2021).