A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project

Delanerolle，Gayathri1; Ramakrishnan，Rema2; Hapangama，Dharani3,4; Zeng，Yutian5; Shetty，Ashish6,7; Elneil，Sohier6,7; Chong，Sam6,7; Hirsch，Martin6,8; Oyewole，Molola6,7; Phiri，Peter9,10; Elliot，Kathryn9; Kothari，Trusha4; Rogers，Bryony3,4; Sandle，Natasha1; Haque，Nyla1; Pluchino，Nicola11; Silem，Martin12; O’Hara，Rebecca13; Hull，M. Louise13; Majumder，Kingshuk14; Shi，Jian Qing5,15; Raymont，Vanessa1,16

2021

10.1177/17455065211019717

Womens Health   影响因子和分区

1745-5057

1745-5065

Background: It is important to evaluate sequalae for complex chronic health conditions such as endometriosis and mental health disorders. Endometriosis impacts 1 in 10 women. Mental health outcomes can be a primary determinant in many physical health conditions although this is an area not well researched particularly in women’s health. This has been problematic for endometriosis patients in particular, who report mental health issues as well as other key comorbidities such as chronic pelvic pain and infertility. This could be partly due to the complexities associated with comprehensively exploring overlaps between physical and mental health disorders in the presence of multiple comorbidities and their potential mechanistic relationship. Methods: In this evidence synthesis, a systematic methodology and mixed-methods approaches were used to synthesize both qualitative and quantitative data to examine the prevalence of the overlapping sequalae between endometriosis and psychiatric symptoms and disorders. As part of this, an evidence synthesis protocol was developed which included a systematic review protocol that was published on PROSPERO (CRD42020181495). The aim was to identify and evaluate mental health reported outcomes and prevalence of symptoms and psychiatric disorders associated with endometriosis. Findings: A total of 34 papers were included in the systematic review and 15 were included in the meta-analysis. Anxiety and depression symptoms were the most commonly reported mental health outcomes while a pooled analysis also revealed high prevalence of chronic pelvic pain and dyspareunia. Interpretation: It is evident that small-scale cross-sectional studies have been conducted in a variety of settings to determine mental health outcomes among endometriosis patients. Further research is required to comprehensively evaluate the mental health sequalae with endometriosis.

adenomyosis BAME chronic pelvic pain dysmenorrhea dyspareunia endometriosis mental health women’s health women’s mental health

英语

其他

2-s2.0-85107245756

Scopus

1.Oxford Brain Health Clinical Trials Unit,University of Oxford,Oxford,United Kingdom
2.Nuffield Department of Women’s & Reproductive Health,University of Oxford,Oxford,United Kingdom
3.University of Liverpool,Liverpool,United Kingdom
4.Liverpool Women’s NHS Foundation,Liverpool,United Kingdom
5.Southern University of Science and Technology,Shenzhen,China
6.University College London Hospitals NHS Foundation Trust,London,United Kingdom
7.University College London,London,United Kingdom
8.Oxford Health NHS Foundation Trust,Oxford,United Kingdom
9.Southern Health NHS Foundation Trust,Southampton,United Kingdom
10.School of Primary Care,Population Sciences and Medical Education,University of Southampton,Southampton,United Kingdom
11.Divisions of Gynecology and Obstetrics,Geneva University Hospitals,Geneva,Switzerland
12.University Medical Center Freiburg,Freiburg,Germany
13.Robinson Research Institute,The University of Adelaide,Adelaide,Australia
14.Manchester University NHS Foundation Trust,Manchester,United Kingdom
15.The Alan Turing Institute,London,United Kingdom
16.Department of Psychiatry,University of Oxford,Oxford,United Kingdom

Delanerolle，Gayathri,Ramakrishnan，Rema,Hapangama，Dharani,et al. A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project[J]. Womens Health,2021,17.

Delanerolle，Gayathri.,Ramakrishnan，Rema.,Hapangama，Dharani.,Zeng，Yutian.,Shetty，Ashish.,...&Raymont，Vanessa.(2021).A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project.Womens Health,17.

Delanerolle，Gayathri,et al."A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project".Womens Health 17(2021).