From phosphorus to phosphorene: Applications in disease theranostics

Zhu，Yao1; Xie，Zhongjian2,3; Li，Jingfeng3,4; Liu，Yingying1; Li，Chaozhou4; Liang，Weiyuan5; Huang，Weichun6; Kang，Jianlong4; Cheng，Faliang7; Kang，Lin8; Al-Hartomy，Omar A.9; Al-Ghamdi，Ahmed9; Wageh，Swelm9; Xu，Jinfeng1; Li，Defa10; Zhang，Han4

2021-11-01

10.1016/j.ccr.2021.214110

COORDINATION CHEMISTRY REVIEWS   影响因子和分区

0010-8545

1873-3840

As one of the main elements in the living organisms, phosphorus makes an important impact on the life activity. Phosphorus contained compounds have been widely applied in the biomedical field. As nanotechnology develops, a variety of phosphorus-based nanomaterials have also been developed for the biomedical application. The recently discovered superior biological property of two-dimensional black phosphorus (2D BP), i.e. phosphorene, including low toxicity and biodegradability, makes it especially outstanding, such as biosensors for the disease diagnosis. Upon light or ultrasound irradiation on the phosphorene, reactive oxygen species (ROS) or heat can be generated for the disease therapy. Moreover, phosphorene can smartly and efficiently deliver drugs. Thus, it is suitable in many single or combined therapy modalities. This short article reviews the progress from phosphorus to phosphorene to be used as biomedical materials, especially the phosphorene as the biosensor and sensitizer for the disease diagnosis and therapy, including the tumor, the neurodegenerative disease, the bone disease and other diseases. The challenges and prospective of the phosphorene for the biomedical applications are also discussed.

Biomedical application Biosensor Disease therapy Phosphorene Phosphorus

SCI

英语

第一 ; 通讯

State Key Research Development Program of China[2019YFB2203503] ; National Natural Science Fund[61875138,61435010,81871358,"U1801254",61961136001,81771841] ; Science and Technology Innovation Commission of Shenzhen["KQTD2015032416270385","JCYJ20180307164612205","GJHZ20180928160209731"] ; CRI project of the National Research Foundation of Korea[2018R1A3B1052702] ; Natural Science Foundation of Guangdong Province[2020A151501612] ; Guangdong Basic and Applied Basic Research Foundation["2019B1515120043","2019A1515111132"] ; Longhua District Science and Innovation Commission[JCYJ201904] ; King Khalid University[KKU/RCAMS/007/21]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000686400300010

ELSEVIER SCIENCE SA

CHEMISTRY

2-s2.0-85109089965

Scopus

1.Shenzhen Medical Ultrasound Engineering Center,Department of Ultrasonography,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China
2.Institute of Pediatrics,Shenzhen Children's Hospital,Shenzhen,518038,China
3.Shenzhen International Institute for Biomedical Research,Shenzhen,518116,China
4.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Institute of Microscale Optoelectronics,and Otolaryngology Department and Biobank of the First Affiliated Hospital,Shenzhen Second People's Hospital,Health Science Center,Shenzhen University,Shenzhen,518060,China
5.Scientific Research Center,Guilin Medical University,Guilin,China
6.Nantong Key Lab of Intelligent and New Energy Materials,College of Chemistry and Chemical Engineering,Nantong University,Nantong,226019,China
7.Guangdong Engineering and Technology Research Center for Advanced Nanomaterials,School of Environment and Civil Engineering,Dongguan University of Technology,Dongguan,523808,China
8.Clinical Medical Research Center,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
9.Department of Physics,Faculty of Science,King Abdulaziz University,Jeddah,21589,Saudi Arabia
10.Department of Laboratory Medicine,Shenzhen Children's Hospital,Shenzhen,518038,China

Zhu，Yao,Xie，Zhongjian,Li，Jingfeng,et al. From phosphorus to phosphorene: Applications in disease theranostics[J]. COORDINATION CHEMISTRY REVIEWS,2021,446.

Zhu，Yao.,Xie，Zhongjian.,Li，Jingfeng.,Liu，Yingying.,Li，Chaozhou.,...&Zhang，Han.(2021).From phosphorus to phosphorene: Applications in disease theranostics.COORDINATION CHEMISTRY REVIEWS,446.

Zhu，Yao,et al."From phosphorus to phosphorene: Applications in disease theranostics".COORDINATION CHEMISTRY REVIEWS 446(2021).