Acute Kidney Injury and Early Predictive Factors in COVID-19 Patients

Liu, Jiaye1; Wang, Tingyan2; Cai, Qingxian1; Huang, Deliang1; Sun, Liqin1; He, Qing1; Wang, Fu-Sheng1,3; Chen, Jun1

2021-07-12

10.3389/fmed.2021.604242

FRONTIERS IN MEDICINE   影响因子和分区

2296-858X

["Objectives: Our objective was to explore the incidence and early predictive factors of acute kidney injury in coronavirus disease 2019 (COVID-19) patients.","Method: We established a retrospective cohort of 408 patients who were admitted to Shenzhen Third People's Hospital in Shenzhen, China, between January 1 and March 31, 2020. Clinical outcomes and renal function were monitored until April 12, 2020, with a median follow-up duration of 21 days [interquartile range (IQR) = 14-33].","Results: When first admitted to hospital (baseline), 19.36% (79/408) presented renal dysfunction [estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m(2)]. During follow-up, 3.9% (16/408) developed acute kidney injury (AKI). Age >= 60 years [hazard ratio (HR) = 4.78, 95% CI = 1.10-20.69], PaO2/FiO(2) ratio < 300 (HR = 3.48, 95% CI = 1.04-11.62), and higher creatinine (HR = 1.04, 95% CI = 1.01-1.07) at baseline independently predicted the risk of AKI. Respectively, 25.0% (102/408), 3.9% (16/408), 0.5% (2/408), 1.0% (4/408), and 0.2% (1/408) experienced G2, G3a, G3b, G4, and G5 as their most severe category during hospitalization, while 69.4% (283/408) had normal eGFRs throughout the follow-up period. When finally discharged from hospital, there were 12.5% (51/408) of patients with abnormal eGFRs.","Conclusions: COVID-19 patients can be at risk of AKI and continuous eGFR decline during hospitalization, which can be early predicted by baseline factors. Some individuals still had renal dysfunction when finally discharged from hospital."]

coronavirus COVID-19 SARS-CoV-2 creatinine eGFR acute kidney injury

SCI

英语

第一 ; 通讯

China Postdoctoral Science Foundation[2019M660840] ; Sanming Project of Medicine in Shenzhen[SZSM201612014]

General & Internal Medicine

Medicine, General & Internal

WOS:000680742700001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Shenzhen, Peoples R China
2.Univ Oxford, Nuffield Dept Med, Oxford, England
3.Peoples Liberat Army Gen Hosp, Treatment & Res Ctr Infect Dis, Med Ctr 5, Beijing, Peoples R China

Liu, Jiaye,Wang, Tingyan,Cai, Qingxian,et al. Acute Kidney Injury and Early Predictive Factors in COVID-19 Patients[J]. FRONTIERS IN MEDICINE,2021,8.

Liu, Jiaye.,Wang, Tingyan.,Cai, Qingxian.,Huang, Deliang.,Sun, Liqin.,...&Chen, Jun.(2021).Acute Kidney Injury and Early Predictive Factors in COVID-19 Patients.FRONTIERS IN MEDICINE,8.

Liu, Jiaye,et al."Acute Kidney Injury and Early Predictive Factors in COVID-19 Patients".FRONTIERS IN MEDICINE 8(2021).