Ultrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry

Min，Siyi1,2; Li，Shijie1; Zhu，Zhouyang1; Liu，Yu1,2; Liang，Chuwei1; Cai，Jingxuan1; Han，Fei2; Li，Yuyan1,2; Cai，Wenshan3; Cheng，Xing2; Li，Wen Di1

2021-07-01

10.1002/adma.202100270

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Highly sensitive detection of trace amounts of substances is crucial for broad applications in healthcare, environmental monitoring, antiterrorism, etc., where cost effectiveness and portability are often demanded. Here, an ultrasensitive sensor is reported that can detect an angstrom-thick layer of adsorbed molecules through image acquisition and processing. The sensor features a centimeter-scale plasmonic metasurface with spatially varying geometry, where the light scattering is dependent on both the adsorbed substances and spatial locations. When illuminated with narrowband light (such as from a light emitting diode), the intensity pattern recorded on the metasurface changes with the surface-adsorbed molecules, enabling label-free, sensitive, and spectrometer-free molecular detection. The centimeter-scale size of the sensing area interfaces well with consumer-level imaging sensors on mobile devices without the need for microscopic optics and offers a high signal-to-noise ratio by leveraging the multimillion pixels for noise reduction. It is experimentally demonstrated that a single layer of AlO molecules deposited on the sensor, with a thickness of approximately one angstrom, can be detected by analyzing the images taken of the sensing chip. Furthermore, by integrating the sensor into a microfluidic setup, quantitative detection of BSA/anti-BSA immune complex formation events is demonstrated, which agrees well with the Langmuir isotherm model.

centimeter-scale metasurfaces deterministic gradient geometry image-based sensing schemes molecular detection

SCI ; EI

英语

NI期刊

其他

WOS:000657695400001

20212310456411

Alumina ; Aluminum oxide ; Cost effectiveness ; Isotherms ; Light ; Light scattering ; mHealth ; Molecules

Information Theory and Signal Processing:716.1 ; Light/Optics:741.1 ; Inorganic Compounds:804.2 ; Industrial Economics:911.2 ; Atomic and Molecular Physics:931.3

MATERIALS SCIENCE

2-s2.0-85107127513

Scopus

1.Department of Mechanical Engineering,The University of Hong Kong,Pokfulam Road,Hong Kong
2.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518052,China
3.School of Electrical and Computer Engineering,Georgia Institute of Technology,Atlanta,30332,United States

Min，Siyi,Li，Shijie,Zhu，Zhouyang,et al. Ultrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry[J]. ADVANCED MATERIALS,2021,33(29).

Min，Siyi.,Li，Shijie.,Zhu，Zhouyang.,Liu，Yu.,Liang，Chuwei.,...&Li，Wen Di.(2021).Ultrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry.ADVANCED MATERIALS,33(29).

Min，Siyi,et al."Ultrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry".ADVANCED MATERIALS 33.29(2021).