Acrylate-Substituted Thiadiazoloquinoxaline Yields Ultralow Band Gap (0.56 eV) Conjugated Polymers for Efficient Photoacoustic Imaging

Luo，Yingtong1; Lan，Yintao2; Peng，Liang1; Qiu，Ting2; Li，Qingduan1; Hou，Qiong1; Liu，Chunchen3; Zhang，Jian2; Cai，Yue Peng1; Liu，Shengjian1

2021-06-11

10.1021/acsapm.1c00464

ACS Applied Polymer Materials   影响因子和分区

2637-6105

Conjugated polymers have been proven to be full of promising application in photoacoustic (PA) imaging. Generally, the absorption spectra of PA contrast agents lying in the near-infrared (NIR) II window are requisite to eliminate the light absorption and scattering of tissue, skin, and blood. In this concise study, strong acceptor acrylate-substituted thiadiazoloquinoxaline (ATQ) was developed and used to copolymerize with different donors, yielding three NIR II polymers. Results show that (i) ATQ-based polymers can reach an ultralow optical band gap of 0.56 eV; (ii) the ATQ-based polymer nanoparticles have good biocompatibility and high PA signal intensity with a tissue penetration depth up to 10 mm; and (iii) under NIR II laser irradiation, the signal-to-noise ratio of mouse cerebrovascular during in vivo PA imaging enhanced by 10 times after injecting ATQ-based nanoparticles. This work reveals that acrylate-substituted ATQ-based polymers, which can be easily synthesized and functionalized, extend the absorption spectra to longer wavelengths, and decrease the radiative decay rate (kr), are a promising class of NIR polymers for developing efficient PA contrast agents.

conjugated polymers nanoparticles narrow band gap near-infrared ii photoacoustic imaging

SCI ; EI

英语

其他

WOS:000662223400040

20212610546248

Biocompatibility ; Energy gap ; Infrared devices ; Light absorption ; Nanoparticles ; Signal to noise ratio ; Tissue

Biological Materials and Tissue Engineering:461.2 ; Immunology:461.9.1 ; Information Theory and Signal Processing:716.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Organic Polymers:815.1.1 ; Solid State Physics:933

2-s2.0-85108371969

Scopus

1.School of Chemistry,Guangzhou Key Laboratory of Materials for Energy Conversion and Storage,Guangdong Prov. Eng. Technology Research Center for Materials for Energy Conversion and Storage,MOE,Key Laboratory of Theoretical Chemistry of the Environment,South China Normal University (SCNU),Guangzhou,510006,China
2.School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou,511436,China
3.Department of Materials Science and Engineering,Shenzhen Key Laboratory of Printed Organic Electronics,Southern University of Science and Technology,Shenzhen,518055,China

Luo，Yingtong,Lan，Yintao,Peng，Liang,et al. Acrylate-Substituted Thiadiazoloquinoxaline Yields Ultralow Band Gap (0.56 eV) Conjugated Polymers for Efficient Photoacoustic Imaging[J]. ACS Applied Polymer Materials,2021,3(6):3247-3253.

Luo，Yingtong.,Lan，Yintao.,Peng，Liang.,Qiu，Ting.,Li，Qingduan.,...&Liu，Shengjian.(2021).Acrylate-Substituted Thiadiazoloquinoxaline Yields Ultralow Band Gap (0.56 eV) Conjugated Polymers for Efficient Photoacoustic Imaging.ACS Applied Polymer Materials,3(6),3247-3253.

Luo，Yingtong,et al."Acrylate-Substituted Thiadiazoloquinoxaline Yields Ultralow Band Gap (0.56 eV) Conjugated Polymers for Efficient Photoacoustic Imaging".ACS Applied Polymer Materials 3.6(2021):3247-3253.