| 题名 | Anticoagulant Hydrogel Tubes with Poly(ɛ-Caprolactone) Sheaths for Small-Diameter Vascular Grafts |
| 作者 | |
| 通讯作者 | Zhou，Fengshan; Jiang，Xingyu |
| 发表日期 | 2021
|
| DOI | |
| 发表期刊 | |
| ISSN | 2192-2640
|
| EISSN | 2192-2659
|
| 卷号 | 10 |
| 摘要 | Small-diameter vascular grafts (inner diameter < 6 mm) are useful in treating cardiovascular diseases. The off-the-shelf small-diameter vascular grafts for clinical applications remain a great limitation owing to their thrombogenicity or intimal hyperplasia. Herein, bilayer anticoagulant hydrogel tubes with poly(ε-caprolactone) (PCL) sheaths are prepared by freeze-thawing and electrospinning, which contain nanofibrillated cellulose (NFC)/poly(vinyl alcohol) (PVA)-heparin/poly-L-lysine nanoparticles tube as an inner layer and PCL sheath as an outer layer. The structure, anticoagulant property, and biocompatibility of the inner layer are studied. The effects of thickness of the outer layer on perfusion performance and mechanical property of hydrogel tubes with PCL sheaths (PCL-NFC/PVA-NPs tubes) are investigated. The effect of compliance of PCL-NFC/PVA-NPs tubes on their blood flow is studied by numerical simulation. The tissue compatibility and the patency of PCL-NFC/PVA-NPs tubes are evaluated by implantation in subcutaneous tissue of rats and carotid artery of rabbits. PCL-NFC/PVA-NPs tubes have prominent anticoagulation, sufficient burst pressure and good compliance similar to native arteries. PCL-NFC/PVA-NPs tubes facilitate infiltration of host cells and achieve active proliferation of recruited cells, which will be a promising candidate for small-diameter vascular grafts. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| WOS记录号 | WOS:000669261500001
|
| EI入藏号 | 20212710589565
|
| EI主题词 | Biocompatibility
; Biomechanics
; Cellulose nanocrystals
; Grafts
; Hydrogels
; Tissue
|
| EI分类号 | Bioengineering and Biology:461
; Prosthetics:462.4
; Pipe, Piping and Pipelines:619.1
; Chemical Products Generally:804
|
| Scopus记录号 | 2-s2.0-85108991048
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：15
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/242284 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes,National Laboratory of Mineral Materials,School of Materials Science and Technology,China University of Geosciences (Beijing),Beijing,No. 29 Xueyuan Road, Haidian District,100083,China 2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao, Haidian District,100190,China 3.Division of Nephrology,Peking University Third Hospital,Beijing,No. 49 Huayuan Road North, Haidian District,100191,China 4.Department of Cardiac Surgery,Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,No. 167 Beilishi Road, Xicheng District,100037,China 5.Animal Experimental Center,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Research and Evaluation for Cardiovascular Implant Materials,Beijing,No. 167 Beilishi Road, Xicheng District,100037,China 6.Department of Pathology,Fuwai Hospital,State Key Laboratory of Cardiovascular Disease,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,No. 167 Beilishi Road, Xicheng District,100037,China 7.Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,No. 2 Anzhen Road, Chaoyang District,100029,China 8.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Road, Nanshan District,518055,China |
| 通讯作者单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Zhang，Chunliang,Xie，Qian,Cha，Ruitao,et al. Anticoagulant Hydrogel Tubes with Poly(ɛ-Caprolactone) Sheaths for Small-Diameter Vascular Grafts[J]. Advanced Healthcare Materials,2021,10.
|
| APA |
Zhang，Chunliang.,Xie，Qian.,Cha，Ruitao.,Ding，Li.,Jia，Liujun.,...&Jiang，Xingyu.(2021).Anticoagulant Hydrogel Tubes with Poly(ɛ-Caprolactone) Sheaths for Small-Diameter Vascular Grafts.Advanced Healthcare Materials,10.
|
| MLA |
Zhang，Chunliang,et al."Anticoagulant Hydrogel Tubes with Poly(ɛ-Caprolactone) Sheaths for Small-Diameter Vascular Grafts".Advanced Healthcare Materials 10(2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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