Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method

Zhu，Daoming1; Zhang，Jing2,3; Luo，Guanghong1; Duo，Yanhong1,4; Tang，Ben Zhong2

2021

10.1002/advs.202004769

Advanced Science   影响因子和分区

2198-3844

While promising, the efficacy of aggregation-induced emission (AIE)-based photodynamic therapy (PDT) is limited by several factors including limited depth of laser penetration and intratumoral hypoxia. In the present study, a novel bacteria-based AIEgen (TBP-2) hybrid system (AE) is developed, that is able to facilitate the hypoxia-tolerant PDT treatment of orthotopic colon tumors via an interventional method. For this approach, an interventional device is initially designed, composed of an optical fiber and an endoscope, allowing for clear visualization of the position of the orthotopic tumor within the abdominal cavity. It is then possible to conduct successful PDT treatment of this hypoxic tumor via laser irradiation, as the TBP-2 is able to generate hydroxyl radicals (•OH) via a type I mechanism within this hypoxic microenvironment. Moreover, this interventional approach is proved to significantly impair orthotopic colon cancer growth and overcame PDT defects. This study is the first report involving such an interventional PDT strategy to knowledge, and it has the potential to complement other treatment modalities while also highlighting novel approaches to the design of hybrid AIEgen systems.

aggregation-induced emission bright bacteria hypoxia-tolerant photodynamic therapy interventional photodynamic therapy orthotopic colon tumors

SCI ; EI

英语

ESI高被引

第一 ; 通讯

WOS:000662850100001

2-s2.0-85107976739

Scopus

1.Department of Radiation Oncology,the Second Clinical Medical College of Jinan University,1st Affiliated Hospital of Southern University of Science and Technology,Shenzhen People's Hospital,Shenzhen,518020,China
2.Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study,The Hong Kong University of Science and Technology,Kowloon,Clear Water Bay,999077,Hong Kong
3.Department of Laboratory Medicine,Nanfang Hospital,Southern Medical University,Guangzhou,510515,China
4.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,Sweden

Zhu，Daoming,Zhang，Jing,Luo，Guanghong,et al. Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method[J]. Advanced Science,2021.

Zhu，Daoming,Zhang，Jing,Luo，Guanghong,Duo，Yanhong,&Tang，Ben Zhong.(2021).Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method.Advanced Science.

Zhu，Daoming,et al."Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method".Advanced Science (2021).