Magnetic black phosphorus microbubbles for targeted tumor theranostics

Zhu，Yao1; Liu，Yingying1; Xie，Zhongjian2; He，Tianzhen1; Su，Lili1; Guo，Fengjuan1; Arkin，Gulzira1; Lai，Xiao Shu1; Xu，Jinfeng1; Zhang，Han3

2021

10.1515/nanoph-2021-0085

Nanophotonics   影响因子和分区

2192-8606

2192-8614

Black phosphorus (BP) is attracting more and more interest for the biomedical application. The absorption in a wide spectral range and high photothermal conversion efficiency make BP suitable for photothermal therapy. However, BP alone is hard to realize the targeted therapy, which limits the precision and efficiency of the therapy. Magnetic microbubbles (MBs) are favored drug carriers because they can resist the sheer force of blood flow in a magnetic field, which improves the efficiency of MBs adhesion to the vascular wall for targeted ultrasound diagnosis and therapy. This study first optimized the magnetic MBs configurations through controlling the connecting polyethylene glycol (PEG) chain length. The magnetic MBs with PEG2000 have been chosen for targeted BP nanosheets delivery due to the better stability and magnetic responsiveness. The magnetic black phosphorus microbubbles (MBBPM) can realize the targeted tumor theranostics in vitro and in vivo. They could be applied for the targeted ultrasound imaging with an enhanced echogenicity by three times when accumulated at the target site where the magnetic field is applied. As the NIR laser irradiation was applied on the accumulated MBBPM, they dynamited and the temperature increased rapidly. It improved the cell membrane permeability, thus accelerating and enhancing a precision photothermal killing effect to the breast cancer cells, compared to BP alone.

black phosphorus magnetic microbubbles photothermal therapy targeted theranostics US imaging

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[81771841] ; Guangdong Basic and Applied Basic Research Foundation["2019A1515111132","2019B1515120043"] ; Science and Technology Project of Shenzhen[JCYJ20180508152903208] ; Natural Science Foundation of Guangdong Province[2020A151501612] ; Longhua District Science and Innovation Commission Project Grants of Shenzhen[JCYJ201904]

Science & Technology - Other Topics ; Materials Science ; Optics ; Physics

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Optics ; Physics, Applied

WOS:000699926300023

WALTER DE GRUYTER GMBH

2-s2.0-85107308652

Scopus

1.Department of Ultrasonography,Shenzhen Medical Ultrasound Engineering Center,Shenzhen People's Hospital,Second Clinical Medical College of Jinan University,First Clinical Medical College of Southern University of Science and Technology,Shenzhen,518020,China
2.Shenzhen International Institute for Biomedical Research,Shenzhen,518116,China
3.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Physics and Optoelectronic Engineering and Otolaryngology,Department and Biobank of the First Affiliated Hospital,Shenzhen Second People's Hospital,Health Science Center,Shenzhen University,Shenzhen,518060,China

Zhu，Yao,Liu，Yingying,Xie，Zhongjian,et al. Magnetic black phosphorus microbubbles for targeted tumor theranostics[J]. Nanophotonics,2021,10(12).

Zhu，Yao.,Liu，Yingying.,Xie，Zhongjian.,He，Tianzhen.,Su，Lili.,...&Zhang，Han.(2021).Magnetic black phosphorus microbubbles for targeted tumor theranostics.Nanophotonics,10(12).

Zhu，Yao,et al."Magnetic black phosphorus microbubbles for targeted tumor theranostics".Nanophotonics 10.12(2021).