Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes

Zhu，Jiefeng1,2; He，Chuan1

2021

10.1055/a-1503-7976

SYNLETT   影响因子和分区

0936-5214

1437-2096

A Rh-catalyzed enantioselective intermolecular dehydrogenative Si-O coupling of dihydrosilanes with alcohols and silanols is demonstrated. Rh(I) catalyst equipped with a Josiphos ligand enables the highly enantioselective alcoholysis process of dihydrosilanes, giving access to a variety of functionalized triorgano-substituted silicon-stereogenic alkoxysilanes and siloxanes in decent yields and ee, which significantly expand the chemical space of the silicon-centered chiral molecules. Utility of this methodology is illustrated by the construction of circularly polarized luminescence (CPL) active chiral alkoxysilane small organic molecules. 1 Introduction 2 Conditions Optimization 3 Substrate Scope 4 Application 5 Conclusions 6 Experimental Procedure.

asymmetric catalysis CPL-active silanes dehydrogenative Si-O coupling silicon-stereogenic alkoxysilanes silicon-stereogenic siloxanes

SCI

英语

第一 ; 通讯

WOS:000658468700001

CHEMISTRY

2-s2.0-85107969187

Scopus

1.Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
2.School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,150080,China

Zhu，Jiefeng,He，Chuan. Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes[J]. SYNLETT,2021.

Zhu，Jiefeng,&He，Chuan.(2021).Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes.SYNLETT.

Zhu，Jiefeng,et al."Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes".SYNLETT (2021).