南方科技大学知识苑(SUSTech KC): Likely Common Role of Hypoxia in Driving F-18-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection

题名	Likely Common Role of Hypoxia in Driving F-18-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection
作者	Yao, Yong 1,2,3; Li, Ya-Ming 4; He, Zuo-Xiang 5; Civelek, A. Cahid 6; Li, Xiao-Feng1,2
通讯作者	Li, Xiao-Feng
发表日期	2021-08-01
DOI	10.1089/cbr.2020.4716
发表期刊	CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 影响因子和分区
ISSN	1084-9785
EISSN	1557-8852
摘要	First introduced in 1976, F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has become an indispensable tool for diagnosis and prognostic evaluation of tumors, heart disease, as well as other conditions, including inflammation and infection. Because F-18-FDG can accurately reflect the glucose metabolism level of organs and tissues, it is known as a "century molecule" and is currently the main agent for PET imaging. The degree of F-18-FDG uptake by cells is related to both the rate of glucose metabolism and glucose transporter expression. These, in turn, are strongly influenced by hypoxia, in which cells meet their energy needs through glycolysis, and F-18-FDG uptake increased due to hypoxia. F-18-FDG uptake is a complex process, and hypoxia may be one of the fundamental driving forces. The correct interpretation of F-18-FDG uptake in PET imaging can help clinics make treatment decisions more accurately and effectively. In this article, we review the application of F-18-FDG PET in tumors, myocardium, and inflammation. We discuss the relationship between F-18-FDG uptake and hypoxia, the possible mechanism of F-18-FDG uptake caused by hypoxia, and the associated clinical implications.
关键词	F-18-FDG uptake cancer hypoxia inflammation myocardial ischemia
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Shenzhen Science Technology Project[JCYJ20190806151003583] ; China Postdoctoral Science Foundation[2020M673079]
WOS研究方向	Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000683489100001
出版者	MARY ANN LIEBERT, INC
ESI学科分类	PHARMACOLOGY & TOXICOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：13
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/242686
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Nucl Med, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Nucl Med, Shenzhen, Peoples R China 3.Jinan Univ, Clin Med Postdoctoral Res Stn, Guangzhou, Peoples R China 4.China Med Univ, Hosp 1, Dept Nucl Med, Shenyang, Peoples R China 5.Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Sch Clin Med, Dept Nucl Med, Beijing, Peoples R China 6.Johns Hopkins Med, Dept Radiol, Div Nucl Med & Mol Imaging, Baltimore, MD USA
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yao, Yong,Li, Ya-Ming,He, Zuo-Xiang,et al. Likely Common Role of Hypoxia in Driving F-18-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2021.
APA	Yao, Yong,Li, Ya-Ming,He, Zuo-Xiang,Civelek, A. Cahid,&Li, Xiao-Feng.(2021).Likely Common Role of Hypoxia in Driving F-18-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection.CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS.
MLA	Yao, Yong,et al."Likely Common Role of Hypoxia in Driving F-18-FDG Uptake in Cancer, Myocardial Ischemia, Inflammation and Infection".CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2021).