南方科技大学知识苑(SUSTech KC): Blood Circulating miRNA Pairs as a Robust Signature for Early Detection of Esophageal Cancer

题名	Blood Circulating miRNA Pairs as a Robust Signature for Early Detection of Esophageal Cancer
作者	Song, Yang; Zhu, Suzhu; Zhang, Ning; Cheng, Lixin
通讯作者	Cheng, Lixin
发表日期	2021-07-23
DOI	10.3389/fonc.2021.723779
发表期刊	Frontiers in Oncology 影响因子和分区
ISSN	2234-943X
卷号	11
摘要	Esophageal cancer (EC) is a common malignant tumor in the digestive system which is often diagnosed at the middle and late stages. Noninvasive diagnosis using circulating miRNA as biomarkers enables accurate detection of early-stage EC to reduce mortality. We built a diagnostic signature consisting of four miRNA pairs for the early detection of EC using individualized Pairwise Analysis of Gene Expression (iPAGE). Profiling of miRNA expression identified 496 miRNA pairs with significant relative expression change. Four miRNA pairs consistently selected from LASSO were used to construct the final diagnostic model. The performance of the signature was validated using two independent datasets, yielding both AUCs and PRCs over 0.99. Furthermore, precision, recall, and F-score were also evaluated for clinical application, when a fixed threshold is given, resulting in all the scores are larger than 0.92 in the training set, test set, and two validation sets. Our results suggested that the 4-miRNA signature is a new biomarker for the early diagnosis of patients with EC. The clinical use of this signature would have improved the detection of EC for earlier therapy and more favorite prognosis.
关键词	microRNA biomarker esophageal cancer (EC) gene pair diagnosis
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Guangdong Basic and Applied Basic Research Foundation[2019A1515110097]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000681627300001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：9
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/242689
专题	南方科技大学第一附属医院
作者单位	Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2, Shenzhen Peoples Hosp,Affiliated Hosp 1, Shenzhen, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Song, Yang,Zhu, Suzhu,Zhang, Ning,et al. Blood Circulating miRNA Pairs as a Robust Signature for Early Detection of Esophageal Cancer[J]. Frontiers in Oncology,2021,11.
APA	Song, Yang,Zhu, Suzhu,Zhang, Ning,&Cheng, Lixin.(2021).Blood Circulating miRNA Pairs as a Robust Signature for Early Detection of Esophageal Cancer.Frontiers in Oncology,11.
MLA	Song, Yang,et al."Blood Circulating miRNA Pairs as a Robust Signature for Early Detection of Esophageal Cancer".Frontiers in Oncology 11(2021).