| 题名 | Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder |
| 作者 | |
| 通讯作者 | Pan, Yihang; Li, Huiliang; Li, Ningning |
| 共同第一作者 | Ju, Jun; Yang, Xiuyan; Jiang, Jian |
| 发表日期 | 2021-08-12
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| DOI | |
| 发表期刊 | |
| EISSN | 1662-5102
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| 卷号 | 15 |
| 摘要 | Myelin abnormalities have been observed in autism spectrum disorder (ASD). In this study, we seek to discover myelin-related changes in the striatum, a key brain region responsible for core ASD features, using the 16p11.2 deletion (16p11.2(+/-)) mouse model of ASD. We found downregulated expression of multiple myelin genes and decreased myelin thickness in the striatum of 16p11.2(+/-) mice versus wild type controls. Moreover, given that myelin is the main reservoir of brain lipids and that increasing evidence has linked dysregulation of lipid metabolism to ASD, we performed lipidomic analysis and discovered decreased levels of certain species of sphingomyelin, hexosyl ceramide and their common precursor, ceramide, in 16p11.2(+/-) striatum, all of which are major myelin components. We further identified lack of ceramide synthase 2 as the possible reason behind the decrease in these lipid species. Taken together, our data suggest a role for myelin and myelin lipids in ASD development. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| 资助项目 | Hundred Talents Program of Sun Yat-sen University[392007]
; National Natural Science Foundation of China[81874176,82072766]
; Shenzhen Sanming Project of Medicine[SZSM201911003]
; Shenzhen Science, Technology and Innovation Commission (SZSTI) Basic Research Program[JCYJ20190809154411427]
; UK Biotechnology Biological Sciences Research Council[
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| WOS研究方向 | Neurosciences & Neurology
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| WOS类目 | Neurosciences
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| WOS记录号 | WOS:000684993800002
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：9
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/242949 |
| 专题 | 生命科学学院_生物系 |
| 作者单位 | 1.Sun Yat Sen Univ, Tomas Lindahl Nobel Laureate Lab, Affiliated Hosp 7, Shenzhen, Peoples R China 2.UCL, Fac Med Sci, Wolfson Inst Biomed Res, Div Med, London, England 3.Hangzhou Normal Univ, Inst Dev & Regenerat Biol, Zhejiang Key Lab Organ Dev & Regenerat, Hangzhou, Peoples R China 4.Sun Yat Sen Univ, Dept Neonatol, Affiliated Hosp 7, Shenzhen, Peoples R China 5.Sun Yat Sen Univ, Affiliated Hosp 7, Clin Neurosci Ctr, Shenzhen, Peoples R China 6.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Anesthesiol, Shenzhen, Peoples R China 7.Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, State Key Lab Oncogen, Shenzhen, Peoples R China 8.Southern Univ Sci & Technol, Brain Res Ctr, Shenzhen, Peoples R China 9.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China 10.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pediat, Guangzhou, Peoples R China 11.Sun Yat Sen Univ, Affiliated Hosp 7, Guangdong Prov Key Lab Digest Canc Res, Shenzhen, Peoples R China 12.China UK Inst Frontier Sci, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Ju, Jun,Yang, Xiuyan,Jiang, Jian,et al. Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2021,15.
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| APA |
Ju, Jun.,Yang, Xiuyan.,Jiang, Jian.,Wang, Dilong.,Zhang, Yumeng.,...&Li, Ningning.(2021).Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder.FRONTIERS IN CELLULAR NEUROSCIENCE,15.
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| MLA |
Ju, Jun,et al."Structural and Lipidomic Alterations of Striatal Myelin in 16p11.2 Deletion Mouse Model of Autism Spectrum Disorder".FRONTIERS IN CELLULAR NEUROSCIENCE 15(2021).
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