| 题名 | ELOVL5-mediated long chain fatty acid elongation contributes to enzalutamide resistance of prostate cancer |
| 作者 | |
| 通讯作者 | Wang，Zhong; Hu，Hailiang; Wang，Zhong; Hu，Hailiang |
| 发表日期 | 2021-08-02
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| DOI | |
| 发表期刊 | |
| EISSN | 2072-6694
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| 卷号 | 13期号:16 |
| 摘要 | Prostate cancer (PCa) exhibits an elevated level of de novo lipogenesis that provides both energy and basic metabolites for its malignant development. Long-chain polyunsaturated fatty acids (PUFAs) are elongated and desaturated from palmitate but their effects on PCa progression remain largely unknown. Here, we showed that PUFAs were significantly upregulated by androgen deprivation therapy (ADT) and elevated in neuroendocrine (NE)-like PCa cells. The key enzyme of PUFA elongation, ELOVL5, was overexpressed in NE-like PCa cells as well. Furthermore, we demonstrated that knocking down ELOVL5 in enzalutamide resistant NE-like PCa cells diminished the neuroendocrine phenotypes and enzalutamide resistance, while overexpressing ELOVL5 augmented the enzalutamide resistance of PCa cells in vitro and in vivo. Mechanistically, ELOVL5-mediated PUFA elongation enhanced the lipid raft-associated AKT-mTOR signaling activation and therefore contributes to the enzalutamide resistance. These findings suggest that ELOLV5-mediated PUFA elongation may be a potential novel target for the treatment of enzalutamide resistant NElike PCa. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | Shanghai Sailing Program[21YF1423300]
; Shanghai Science Foundation[21ZR1437800]
; Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine[YG2021QN75]
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| WOS研究方向 | Oncology
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| WOS类目 | Oncology
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| WOS记录号 | WOS:000688848700001
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| 出版者 | |
| Scopus记录号 | 2-s2.0-85112661014
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| 来源库 | Scopus
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| 引用统计 |
被引频次[WOS]：13
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/243009 |
| 专题 | 南方科技大学医学院_生物化学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Urology,Shanghai Ninth People’s Hospital,Shanghai,200011,China 2.Department of Urology,Shanghai Changhai Hospital,Shanghai,200433,China 3.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 4.Department of Urology,Minimally Invasive Surgery Center,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China 5.Guangdong Key Laboratory of Urology,Guangzhou,510120,China 6.Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei,230022,China 7.Department of Urology,Shanghai Ninth People’s Hospital,Shanghai,200011,China 8.Department of Urology,Shanghai Changhai Hospital,Shanghai,200433,China 9.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 10.Department of Urology,Minimally Invasive Surgery Center,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China 11.Guangdong Key Laboratory of Urology,Guangzhou,510120,China 12.Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei,230022,China |
| 通讯作者单位 | 生物化学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Xu，Huan,Li，Sangsang,Sun，Yi,et al. ELOVL5-mediated long chain fatty acid elongation contributes to enzalutamide resistance of prostate cancer[J]. Cancers,2021,13(16).
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| APA |
Xu，Huan.,Li，Sangsang.,Sun，Yi.,Xu，Lingfan.,Hong，Xin.,...&Hu，Hailiang.(2021).ELOVL5-mediated long chain fatty acid elongation contributes to enzalutamide resistance of prostate cancer.Cancers,13(16).
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| MLA |
Xu，Huan,et al."ELOVL5-mediated long chain fatty acid elongation contributes to enzalutamide resistance of prostate cancer".Cancers 13.16(2021).
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| cancers-13-03957-v2.（3597KB） | -- | -- | 开放获取 | -- | 浏览 | |
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