Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19

Zhang，Lina1; Han，Huanqin2; Li，Xuan1; Chen，Caozhen3; Xie，Xiaobing4; Su，Guomei4; Ye，Shicai5; Wang，Cuili4; He，Qing1; Wang，Fang1; Huang，Fang1; Wang，Zhaoqin6; Wu，Jiayuan4; Lai，Tianwen4

2021

10.1177/17562848211035670

Therapeutic Advances in Gastroenterology   影响因子和分区

1756-283X

1756-2848

Background and aims: Currently, there are no definitive therapies for coronavirus disease 2019 (COVID-19). Gut microbial dysbiosis has been proved to be associated with COVID-19 severity and probiotics is an adjunctive therapy for COIVD-19. However, the potential benefit of probiotics in COVID-19 has not been studied. We aimed to assess the relationship of probiotics use with clinical outcomes in patients with COVID-19. Methods: We conducted a propensity-score matched retrospective cohort study of adult patients with COVID-19. Eligible patients received either probiotics plus standard care (probiotics group) or standard care alone (non-probiotics group). The primary outcome was the clinical improvement rate, which was compared among propensity-score matched groups and in the unmatched cohort. Secondary outcomes included the duration of viral shedding, fever, and hospital stay. Results: Among the propensity-score matched groups, probiotics use was related to clinical improvement rates (log-rank p = 0.028). This relationship was driven primarily by a shorter (days) time to clinical improvement [difference, −3 (−4 to −1), p = 0.022], reduction in duration of fever [−1.0 (−2.0 to 0.0), p = 0.025], viral shedding [−3 (−6 to −1), p < 0.001], and hospital stay [−3 (−5 to −1), p = 0.009]. Using the Cox model with time-varying exposure, use of probiotics remained independently related to better clinical improvement rate in the unmatched cohort. Conclusion: Our study suggested that probiotics use was related to improved clinical outcomes in patients with COVID-19. Further studies are required to validate the effect of probiotics in combating the COVID-19 pandemic.

clinical improvement COVID-19 gut microbiota probiotics

SCI

英语

第一

Guangdong Basic and Applied Basic Research Foundation["2020B1515020004","2021A1515011056","2018A0303130269"] ; National Natural Science Foundation of China[81873404] ; Guangdong Medical Science and Technology Research Fund["B2021206","A2018162"] ; Project of Young Innovative Talents in Colleges and Universities in Guangdong Province[2018KQNCX095] ; Shenzhen Key Medical Discipline Construction Fund[SZXK076] ; Sanming Project of Medicine in Shenzhen[SZSM201612014]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:000688000700001

SAGE PUBLICATIONS LTD

2-s2.0-85112603466

Scopus

1.Department of Liver Diseases,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.Infectious Diseases Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
3.Department of Breast Surgery,the Second Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
4.Department of Respiratory and Critical Care Medicine,Affiliated Hospital,Institute of Respiratory Diseases,Guangdong Medical University,Zhanjiang,China
5.Department of Gastroenterology,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
6.Department of Liver Diseases,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China

Zhang，Lina,Han，Huanqin,Li，Xuan,et al. Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19[J]. Therapeutic Advances in Gastroenterology,2021,14.

Zhang，Lina.,Han，Huanqin.,Li，Xuan.,Chen，Caozhen.,Xie，Xiaobing.,...&Lai，Tianwen.(2021).Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19.Therapeutic Advances in Gastroenterology,14.

Zhang，Lina,et al."Probiotics use is associated with improved clinical outcomes among hospitalized patients with COVID-19".Therapeutic Advances in Gastroenterology 14(2021).