Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences

Feng，Zhe1,2; Jia，Bowen1; Zhang，Mingjie3

2021

10.1021/acs.biochem.1c00376

BIOCHEMISTRY   影响因子和分区

0006-2960

1520-4995

Extensive studies in the past few years have shown that nonmembrane bound organelles are likely assembled via liquid-liquid phase separation (LLPS), a process that is driven by multivalent protein-protein and/or protein-nucleic acid interactions. Both stoichiometric molecular interactions and intrinsically disordered region (IDR)-driven interactions can promote the assembly of membraneless organelles, and the field is currently dominated by IDR-driven biological condensate formation. Here we discuss recent studies that demonstrate the importance of specific biomolecular interactions for functions of diverse physiological condensates. We suggest that phase separation based on combinations of specific interactions and promiscuous IDR-driven interactions is likely a general feature of biological condensation under physiological conditions.

SCI ; EI

英语

通讯

Minister of Science and Technology of China[2019YFA0508402] ; RGC of Hong Kong["AoE-M09-12","C6004-17G"] ; Human Frontier Science Program Research Grant[RGP0020/2019] ; Simons Foundation for Autism Research[510178] ; RGC GRF grant[16102120]

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:000685204700006

AMER CHEMICAL SOC

20213310767714

Liquids ; Molecular interactions ; Molecular structure ; Nucleic acids ; Physiology ; Proteins

Biology:461.9 ; Thermodynamics:641.1 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

BIOLOGY & BIOCHEMISTRY

2-s2.0-85112354364

Scopus

1.Division of Life Science,Hong Kong University of Science and Technology,Kowloon,Clear Water Bay,Hong Kong
2.School of Life Sciences,Fudan University,Shanghai,200433,China
3.School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China

Feng，Zhe,Jia，Bowen,Zhang，Mingjie. Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences[J]. BIOCHEMISTRY,2021,60(31):2397-2406.

Feng，Zhe,Jia，Bowen,&Zhang，Mingjie.(2021).Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences.BIOCHEMISTRY,60(31),2397-2406.

Feng，Zhe,et al."Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences".BIOCHEMISTRY 60.31(2021):2397-2406.