Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections

Xie，Yangzhouyun1; Zhang，Qiang2; Zheng，Wenfu2; Jiang，Xingyu1

2021

10.1021/acsami.1c04944

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

With the long-term and extensive abuse of antibiotics, bacteria can mutate into multidrug-resistant (MDR) strains, resist the existing antibiotics, and escape the danger of being killed. MDR bacteria-caused skin infections are intractable and chronic, becoming one of the most significant and global public-health issues. Thus, the development of novel antimicrobial materials is urgently needed. Non-antibiotic small molecule-modified gold nanoclusters (AuNCs) have great potential as a substitute for commercial antibiotics. Still, their narrow antibacterial spectrum hinders their wide clinical applications. Herein, we report that 4,6-diamino-2-pyrimidinethiol (DAPT)-modified AuNCs (DAPT-AuNCs) can fight against Gram-negative and Gram-positive bacterial strains as well as their MDR counterparts. By modifying DAPT-AuNCs on nanofibrous films, we develop an antibiotic film as innovative dressings for curing incised wounds, which exhibits excellent therapeutic effects on wounds infected by MDR bacteria. Compared to the narrow-spectral one, the broad-spectral antibacterial activity of the DAPT-AuNCs-modified film is more suitable for preventing and treating skin infections caused by various kinds of unknown bacteria. Moreover, the antibacterial films display excellent biocompatibility, implying the great potential for clinical applications.

broad antibacterial activity electrospinning gold nanoclusters nanofibrous membrane wound healing

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[32071390,81730051] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Key R&D Program of China[2018YFA0902600] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000683741400006

AMER CHEMICAL SOC

20213310767938

Antibiotics ; Bacteria ; Biocompatibility ; Curing ; Gold ; Molecules ; Nanoclusters

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Precious Metals:547.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Atomic and Molecular Physics:931.3 ; Solid State Physics:933

2-s2.0-85112314851

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088, Xueyuan Road, Xili, Nanshan District, Guangdong,518055,China
2.Gba Research Innovation Institute for Nanotechnology,Cas Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China

Xie，Yangzhouyun,Zhang，Qiang,Zheng，Wenfu,et al. Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections[J]. ACS Applied Materials & Interfaces,2021,13(30):35306-35314.

Xie，Yangzhouyun,Zhang，Qiang,Zheng，Wenfu,&Jiang，Xingyu.(2021).Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections.ACS Applied Materials & Interfaces,13(30),35306-35314.

Xie，Yangzhouyun,et al."Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections".ACS Applied Materials & Interfaces 13.30(2021):35306-35314.