南方科技大学知识苑(SUSTech KC): Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds

题名	Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds
作者	Yu, Shujuan 1; Sun, Gaohui 1; Sui, Yaqun 1; Li, Hanlin 1; Mai, Yuhan 1; Wang, Guodong 1; Zhang, Ning 2; Bi, Yuhai 2,3; Gao, George F.2,3; Xu, Peng 4; Jiang, Longguang 1; Yuan, Cai 4; Yang, Yang 5 ; Huang, Mingdong 1
通讯作者	Yuan, Cai; Yang, Yang; Huang, Mingdong
发表日期	2021-10-01
DOI	10.1016/j.dyepig.2021.109570
发表期刊	DYES AND PIGMENTS 影响因子和分区
ISSN	0143-7208
EISSN	1873-3743
卷号	194
摘要	The ongoing pandemic of coronavirus disease 2019 (COVID-19) posed a major challenge to the public health. Currently, no proven antiviral treatment for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is available. Here we report compounds pentalysine beta-carbonylphthalocyanine zinc (ZnPc5K) and chlorin e6 (ce6) potently inhibited the viral infection and replication in vitro with EC50 values at nanomolar level. These compounds were first identified by screening a panel of photosensitizers for photodynamic viral inactivation. Such viral inactivation strategy is implementable, and has unique advantages, including resistance to virus mutations, affordability compared to the monoclonal antibodies, and lack of long-term toxicity.
关键词	COVID-19 SARS-CoV-2 inactivation Photodynamic Photosensitizer
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	通讯
资助项目	National Key R&D Program of China[2017YFE0103200] ; National Natural Science Foundation of China[31670739,22077016,82070142,31870163] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB29010102] ; NSFC Outstanding Young Scholars[31822055] ; Youth Innovation Promotion Association of CAS[2017122]
WOS研究方向	Chemistry ; Engineering ; Materials Science
WOS类目	Chemistry, Applied ; Engineering, Chemical ; Materials Science, Textiles
WOS记录号	WOS:000685515200002
出版者	ELSEVIER SCI LTD
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：10
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/244946
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China 2.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, CAS TWAS Ctr Excellence Emerging Infect Dis CEEID, Inst Microbiol,CAS Key Lab Pathogen Microbiol & I, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 4.Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350108, Fujian, Peoples R China 5.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen Key Lab Pathogen & Immun,Second Hosp, Shenzhen, Peoples R China
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yu, Shujuan,Sun, Gaohui,Sui, Yaqun,et al. Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds[J]. DYES AND PIGMENTS,2021,194.
APA	Yu, Shujuan.,Sun, Gaohui.,Sui, Yaqun.,Li, Hanlin.,Mai, Yuhan.,...&Huang, Mingdong.(2021).Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds.DYES AND PIGMENTS,194.
MLA	Yu, Shujuan,et al."Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds".DYES AND PIGMENTS 194(2021).