Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus

Hukportie, Daniel Nyarko1; Li, Fu-Rong1,2; Zhou, Rui1; Zheng, Jia-Zhen1; Wu, Xiao-Xiang3; Wu, Xian-Bo1

2021-08-04

10.3389/fendo.2021.706845

Frontiers in Endocrinology   影响因子和分区

1664-2392

["Background The prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.","Methods Data from the participants with type 2 diabetes mellitus (T2DM) in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study were used to examine the sex-specific association between waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) with incident DN risk.","Results Among the 8,887 participants with T2DM (5,489 men and 3,398 women), 5,296 participants (3,345 men and 1,951 women) developed the DN composite outcome during a follow-up period of 24302 person-years. Among men, null associations were observed between all anthropometric measures with incident DN in the multivariate analysis although the 3(rd) quartile of WHtR showed marginally significant results (P = 0.052). However, among women, both central and general obesity measures were associated with increased risks of incident DN. Compared with participants in the WC <88 cm category, the fully adjusted HR and 95% CI for those in the >= 88 cm of WC was 1.35 (95% CI 1.15-1.57). Compared with the lowest quartile, the fully adjusted HRs and 95% CIs for the 2(nd) to the 4(th) quartile of WHtR were 1.09 (95% CI 0.96-1.25), 1.12 (95% CI 0.98-1.28), and 1.14 (95% CI 1.00-1.30) respectively; also, compared with the normal BMI category, the fully adjusted HRs and 95% CIs for class I - class III obese were 1.36 (95% CI 1.10 - 1.67), 1.43 (95% CI 1.16 - 1.78) and 1.32 (95% CI 1.05 - 1.66) respectively.","Conclusions Among participants with T2DM, higher levels of both central and general obesity indexes were associated with DN risk among women but not in men. Women with T2DM should maintain a healthy weight targeted at reducing both central and general obesity to enhance nephroprotection. Trial registration: ClinicalTrials.gov., no. NCT00000620."]

obesity waist circumference waist-to-height ratio body mass index diabetic nephropathy

SCI

英语

其他

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000687215600001

FRONTIERS MEDIA SA

Web of Science

1.Southern Med Univ, Guangdong Prov Key Lab Trop Dis Res, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Gen Hosp Guangzhou Mil Command, Hosp 157, Dept Gen Sungety, Guangzhou, Peoples R China

Hukportie, Daniel Nyarko,Li, Fu-Rong,Zhou, Rui,et al. Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus[J]. Frontiers in Endocrinology,2021,12.

Hukportie, Daniel Nyarko,Li, Fu-Rong,Zhou, Rui,Zheng, Jia-Zhen,Wu, Xiao-Xiang,&Wu, Xian-Bo.(2021).Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus.Frontiers in Endocrinology,12.

Hukportie, Daniel Nyarko,et al."Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus".Frontiers in Endocrinology 12(2021).