Highly doped NaErF4-based nanocrystals for multi-tasking application

Xie，Yulin1; Chen，Qing1; Wang，Man1; Chen，Weilin1; Quan，Zewei2; Li，Chunxia1

2021

10.1016/j.jre.2021.04.014

JOURNAL OF RARE EARTHS   影响因子和分区

1002-0721

How to engineer single nanocrystal to achieve multiple functions is still a huge challenge. In this work, a novel highly doped rare earth nanocrystal NaErF@NaGdF@NaDyF (Er@Gd@Dy) was designed and fabricated, which exhibits various performances by itself, including the longitudinal (T) and transverse relaxation time (T) double-mode magnetic resonance imaging (MRI), upconversion luminescence and down-shifting luminescence. Upon irradiation of 808 nm near-infrared (NIR) light, the upconverted red light can indirectly activate the photosensitizer Ce6 conjugated on the surface of nanocrystals for photodynamic therapy (PDT). In vivo experiments demonstrate that the nanomaterials can eradicate notably primary tumors without obvious systematic toxicity. In addition, the longitudinal and transverse relaxation rates of Er@Gd@Dy are 24.83 and 319.86 (mmol/L)/s, respectively, which are superior to those of the nanocrystals reported previously. Simultaneously, the nanocrystals have the ability to generate NIR-II light located at 1530 nm, favorable in bioimaging in deeper tissues. As a consequence, this new nanoplatform will advance the improvement of multimodal imaging guided tumor diagnosis and treatment.

MRI NIR-II window Photodynamic therapy Rare earth nanocrystals Upconversion

SCI ; EI

英语

其他

National Natural Science Foundation of China[51872263,52050077,51772142] ; Taishan Scholars Project[ts20190911] ; Shandong Natural Science Foundation[ZR2020ZD36] ; Zhejiang Natural Science Foundation[LZ19E020001] ; Shenzhen Science and Technology Innovation Committee[JCYJ20170412152528921] ; Open Funds of the State Key Laboratory of Rare Earth Resource Utilization[RERU2020005]

Chemistry

Chemistry, Applied

WOS:000719895400002

ELSEVIER

20213410804256

Diagnosis ; Infrared devices ; Light ; Luminescence ; Magnetic resonance imaging ; Photodynamic therapy ; Photosensitizers ; Rare earths ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Inorganic Compounds:804.2

CHEMISTRY

2-s2.0-85113164625

Scopus

1.Institute of Molecular Sciences and Engineering,Institute of Frontier and Interdisciplinarity Science,Shandong University,Qingdao,266237,China
2.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China

Xie，Yulin,Chen，Qing,Wang，Man,et al. Highly doped NaErF4-based nanocrystals for multi-tasking application[J]. JOURNAL OF RARE EARTHS,2021,39(12):1467-1476.

Xie，Yulin,Chen，Qing,Wang，Man,Chen，Weilin,Quan，Zewei,&Li，Chunxia.(2021).Highly doped NaErF4-based nanocrystals for multi-tasking application.JOURNAL OF RARE EARTHS,39(12),1467-1476.

Xie，Yulin,et al."Highly doped NaErF4-based nanocrystals for multi-tasking application".JOURNAL OF RARE EARTHS 39.12(2021):1467-1476.