Ultracompact high-resolution photoacoustic microscopy of hemorrhagic shock

Chen, Qian; Xi, Lei

10.1117/12.2506218

2019

1605-7422

1996-756X

PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2019

10878

San Francisco, CA, United states

1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA

SPIE-INT SOC OPTICAL ENGINEERING

Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here, we proposed an ultracompact photoacoustic microscope to assess hemorrhagic shock by using a rat model. In animal study, hemodynamic features of the microvascular network including concentration of total hemoglobin ( CHbT) and small vascular density ( SVD) were derived to assess the microvascular hemodynamics of different organs, assessing the hemorrhagic shock via microcirculation. On the other hand, in vivo oral imaging of healthy volunteers also indicates the translational possibility of this technique for clinical evaluation of hemorrhagic shock.

hemorrhagic shock U-ORPAM microcirculation organs oral imaging

第一 ; 通讯

英语

CPCI-S ; EI

National Natural Science Foundation of China[61775028] ; National Natural Science Foundation of China[81571722] ; National Natural Science Foundation of China[61528401]

Optics ; Radiology, Nuclear Medicine & Medical Imaging

Optics ; Radiology, Nuclear Medicine & Medical Imaging

WOS:000484589800036

20192006914979

Blood vessels ; Microcirculation ; Photons ; Ultrasonic applications

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Imaging Techniques:746 ; Ultrasonic Applications:753.3 ; Atomic and Molecular Physics:931.3

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Chen, Qian,Xi, Lei. Ultracompact high-resolution photoacoustic microscopy of hemorrhagic shock[C]. 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA:SPIE-INT SOC OPTICAL ENGINEERING,2019.