Long-term photoacoustic brain imaging in a freely moving rat

Chen, Qian; Xi, Lei

10.1117/12.2507790

2019

1605-7422

1996-756X

NEURAL IMAGING AND SENSING 2019

10865

San Francisco, CA, United states

1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA

SPIE-INT SOC OPTICAL ENGINEERING

Photoacoustic microscopy (PAM) is an emerging technique extensively used to study brain activities. However, limited by the size and performance of optical/acoustic scanners, existing ORPAMs are still bulky, heavy, and suffer from low imaging quality/speed. Here, we develop a wearable ORPAM probe featuring small, light, fast, and cellular imaging capability. To evaluate the probe, we monitored the cerebral vascular network within two hours and demonstrated that the microscope was stable enough to study long-term brain hemodynamics in a freely moving rat.

miniaturized ORPAM cerebral hemodynamics ischemia

第一 ; 通讯

英语

CPCI-S ; EI

National Natural Science Foundation of China[61775028] ; National Natural Science Foundation of China[81571722] ; National Natural Science Foundation of China[61528401]

Engineering ; Neurosciences & Neurology ; Optics

Engineering, Biomedical ; Neuroimaging ; Optics

WOS:000468077700011

20192006932392

Brain mapping ; Hemodynamics ; Photoacoustic microscopy ; Probes ; Rats

Biomedical Engineering:461.1 ; Imaging Techniques:746

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Chen, Qian,Xi, Lei. Long-term photoacoustic brain imaging in a freely moving rat[C]. 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA:SPIE-INT SOC OPTICAL ENGINEERING,2019.