Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer

Zhang, Zhen1,2; Li, Jun-wei3,4; Zeng, Pu-hua5; Gao, Wen-hui2; Tian, Xue-fei1,2

2021-08-01

10.1007/s11655-021-3449-8

Chinese Journal of Integrative Medicine   影响因子和分区

1672-0415

1993-0402

Objective To identify specific Chinese medicines (CM) that may benefit patients with primary liver cancer (PLC), and to explore the mechanism of action of these medicines. Methods In this retrospective, singlecenter study, prescription information from PLC patients was used in combination with Traditional Chinese Medicine Inheritance Supports System to identify the specific core drugs. A system pharmacology approach was employed to explore the mechanism of action of these medicines. Results Taking CM more than 6 months was significantly associated with improved survival outcomes. In total, 77 putative targets and 116 bioactive ingredients of the core drugs were identified and included in the analysis (P<0.05). A total of 1,036 gene ontology terms were found to be enriched in PLC. A total of 75 pathways identified from Kyoto Encyclopedia of Genes and Genomes were also enriched in this disease, including fluid shear stress, interleukin-17 signaling, signaling between advanced glycan end products and their receptors, cellular senescence, tumor necrosis factor signaling, p53 signaling, cell cycle signaling, steroid hormone biosynthesis, T-helper 17 cell differentiation, and metabolism of xenobiotics by cytochrome. Docking studies suggested that the ingredients in the core drugs exert therapeutic effects in PLC by modulating c-Jun and interleukin-6. Conclusions Receiving CM for 6 months or more improves survival for the patients with PLC. The core drugs that really benefit for PLC patients likely regulates the tumor microenvironment and tumor itself.

Chinese medicine primary liver cancer system pharmacology bioinformatics tumor microenvironment

SCI

英语

其他

Integrative & Complementary Medicine

Integrative & Complementary Medicine

WOS:000688388500004

SPRINGER

Web of Science

1.Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha 410208, Peoples R China
2.Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Pharm, Shenzhen 518020, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
5.Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Oncol, Changsha 410006, Peoples R China

Zhang, Zhen,Li, Jun-wei,Zeng, Pu-hua,et al. Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer[J]. Chinese Journal of Integrative Medicine,2021.

Zhang, Zhen,Li, Jun-wei,Zeng, Pu-hua,Gao, Wen-hui,&Tian, Xue-fei.(2021).Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer.Chinese Journal of Integrative Medicine.

Zhang, Zhen,et al."Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary Liver Cancer".Chinese Journal of Integrative Medicine (2021).