Synthesis of the Proposed Structures of Parvistemoamide and Their Transformations to Stemoamide Derivatives

Cao，Fei1; Gao，Weiwei1; Wang，Xiaodong2; Zhang，Zhihan3; Yin，Gaofeng2; Wang，Yuqing2; Li，Zhao2; Shi，Tao2; Hou，Yongsheng2; Chen，Jinhong2; Wang，Zhen1,2

2021

10.1021/acs.orglett.1c01045

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

The proposed structures of parvistemoamide have been achieved by macrolactamization, but none of the characterization data of synthetic samples matched with those of the natural sample. The transformation of the highly strained 10-membered lactam ring in parvistemoamide into the pyrrolo[1,2-a]-azepine nucleus in stemoamide is accomplished for the first time by either transannular cyclization or Pilli's transformation. This research may promote the total synthesis of other more complex stemoamide-type or medium-sized-ring-containing Stemona alkaloids.

SCI

英语

NI期刊

其他

Gansu Province Science Foundation for Distinguished Young Scholars[20JR5RA304]

Chemistry

Chemistry, Organic

WOS:000687930500007

AMER CHEMICAL SOC

CHEMISTRY

2-s2.0-85113590319

Scopus

1.State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Ministry of Education of China,Lanzhou,Gansu,730000,China
2.School of Pharmacy,Lanzhou University,Ministry of Education of China,Lanzhou,Number 199 West Donggang Road, Gansu,730000,China
3.Department of Chemistry,Southern University of Science and Technology,Guangdong,Shenzhen,518055,China

Cao，Fei,Gao，Weiwei,Wang，Xiaodong,et al. Synthesis of the Proposed Structures of Parvistemoamide and Their Transformations to Stemoamide Derivatives[J]. ORGANIC LETTERS,2021,23(16).

Cao，Fei.,Gao，Weiwei.,Wang，Xiaodong.,Zhang，Zhihan.,Yin，Gaofeng.,...&Wang，Zhen.(2021).Synthesis of the Proposed Structures of Parvistemoamide and Their Transformations to Stemoamide Derivatives.ORGANIC LETTERS,23(16).

Cao，Fei,et al."Synthesis of the Proposed Structures of Parvistemoamide and Their Transformations to Stemoamide Derivatives".ORGANIC LETTERS 23.16(2021).