Trans-ethnic genome-wide association study of severe COVID-19

Wu, Peng1,2; Ding, Lin3,4; Li, Xiaodong5,6; Liu, Siyang7; Cheng, Fanjun8; He, Qing9; Xiao, Mingzhong5,6; Wu, Ping1,2; Hou, Hongyan2,10; Jiang, Minghui3,4; Long, Pinpin4,11; Wang, Hao4,11; Liu, Linlin12; Qu, Minghan3,4; Shi, Xian3,4; Jiang, Qin4,11; Mo, Tingting4,11; Ding, Wencheng1,2; Fu, Yu1,2; Han, Shi12; Huo, Xixiang12; Zeng, Yingchun12; Zhou, Yana5,6; Zhang, Qing5,6; Ke, Jia5,6; Xu, Xi5,6; Ni, Wei5,6; Shao, Zuoyu5,6; Wang, Jingzhi5,6; Liu, Panhong13; Li, Zilong13; Jin, Yan14; Zheng, Fang15; Wang, Fang9; Liu, Lei9; Li, Wending4,11; Liu, Kang4,11; Peng, Rong4,11; Xu, Xuedan4,11; Lin, Yuhui4,11; Gao, Hui4,11; Shi, Limei4,11; Geng, Ziyue4,11; Mu, Xuanwen4,11; Yan, Yu3,4; Wang, Kai3,4; Wu, Degang3,4; Hao, Xingjie3,4; Cheng, Shanshan3,4; Qiu, Gaokun4,11; Guo, Huan4,11; Li, Kezhen1,2; Chen, Gang1,2; Sun, Ziyong2,10; Lin, Xihong16,17,18; Jin, Xin19; Wang, Feng2,10; Sun, Chaoyang1,2; Wang, Chaolong2,3,4

2021-08-31

10.1038/s42003-021-02549-5

COMMUNICATIONS BIOLOGY   影响因子和分区

2399-3642

["COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus: an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 x 10(-10), allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 x 10(-9), AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 x 10(-8), AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19.","Chaolong Wang and colleagues report a large genome-wide association study for COVID-19 severity in Chinese individuals. By meta-analysis with European data, they identify 3 loci associated with severe disease that suggest key roles for the adaptive immune system and the ABO blood group system in development of severe COVID-19."]

SCI

英语

其他

Wuhan Municipal Health Commission[EG20B03] ; Natural Science Foundation of China[81973148,82003561,32000398,31900487] ; Natural Science Foundation of Guangdong Province[2017A030306026] ; Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases[2019B121205005]

Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics

Biology ; Multidisciplinary Sciences

WOS:000692400100003

NATURE PORTFOLIO

Web of Science

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13.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
14.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Emergency, Wuhan, Peoples R China
15.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China
16.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
17.Harvard Univ, Dept Stat, Cambridge, MA 02138 USA
18.Broad Inst MIT & Harvard, Cambridge, MA USA
19.South China Univ Technol, Sch Med, Guangzhou, Peoples R China

Wu, Peng,Ding, Lin,Li, Xiaodong,et al. Trans-ethnic genome-wide association study of severe COVID-19[J]. COMMUNICATIONS BIOLOGY,2021,4(1).

Wu, Peng.,Ding, Lin.,Li, Xiaodong.,Liu, Siyang.,Cheng, Fanjun.,...&Wang, Chaolong.(2021).Trans-ethnic genome-wide association study of severe COVID-19.COMMUNICATIONS BIOLOGY,4(1).

Wu, Peng,et al."Trans-ethnic genome-wide association study of severe COVID-19".COMMUNICATIONS BIOLOGY 4.1(2021).