Epidermal Sensor for Potentiometric Analysis of Metabolite and Electrolyte

Mou, Lei1,2; Xia, Yong1; Jiang, Xingyu1,2

2021-08-24

10.1021/acs.analchem.1c01940

ANALYTICAL CHEMISTRY   影响因子和分区

0003-2700

1520-6882

Wearable epidermal sensors that can provide noninvasive and continuous analysis of metabolites and electrolytes in sweat have great significance for healthcare monitoring. This study reports an epidermal sensor that can wirelessly, noninvasively, and potentiometrically analyze metabolites and electrolytes. Potentiometry-based ion-selective electrodes (ISE) are most widely used for detecting electrolytes, such as Na+ and K+. We develop an enzyme-based glucose ISE for potentiometric analysis of sweat glucose. The glucose ISE sensor is obtained by modifying a glucose oxidase layer (GOD) on an H+ ISE sensor. GOD catalyzes glucose to generate H+. The generated H+ passes through the H+ selective membrane to change the potential of the electrode. We have fully examined the limit of detection, detecting range, and stability of our epidermal sensor. Meanwhile, using this epidermal sensor, we can easily analyze the relationship between blood glucose and sweat glucose. The concentration curve of sweat glucose can represent blood glucose concentration, significantly contributing to sports and chronic disease monitoring.

SCI ; EI

英语

NI论文

通讯

National Key R&D Program of China["2018YFA0902600","2017YFA0205901"] ; National Natural Science Foundation of China[21535001,81730051,21761142006] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","XDA16020902"] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Guangzhou Municipal Science and Technology Bureau[202002020085] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Chemistry

Chemistry, Analytical

WOS:000691297400021

AMER CHEMICAL SOC

20213610849067

Biomolecules ; Blood ; Electrolytes ; Glucose ; Glucose oxidase ; Glucose sensors ; Ion selective electrodes ; Metabolites ; Potentiometers (electric measuring instruments)

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Biomedical Equipment, General:462.1 ; Electric Batteries and Fuel Cells:702 ; Chemical Plants and Equipment:802.1 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Electric and Electronic Instruments:942.1

CHEMISTRY

Web of Science

1.Guangzhou Med Univ, Dept Clin Lab, Affiliated Hosp 3, Guangzhou 510150, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Mou, Lei,Xia, Yong,Jiang, Xingyu. Epidermal Sensor for Potentiometric Analysis of Metabolite and Electrolyte[J]. ANALYTICAL CHEMISTRY,2021,93(33):11525-11531.

Mou, Lei,Xia, Yong,&Jiang, Xingyu.(2021).Epidermal Sensor for Potentiometric Analysis of Metabolite and Electrolyte.ANALYTICAL CHEMISTRY,93(33),11525-11531.

Mou, Lei,et al."Epidermal Sensor for Potentiometric Analysis of Metabolite and Electrolyte".ANALYTICAL CHEMISTRY 93.33(2021):11525-11531.