Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters

Guo，Yu1; Luo，Ying1; Mu，Shiqiang1; Xu，Jian1; Song，Qiuling1,2

2021

10.1021/acs.orglett.1c02300

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

A visible-light-induced protocol for the synthesis of phosphorothioates is developed by employing the Ir-catalyzed decarboxylative phosphorothiolation of N-hydroxyphthalimide esters. This novel synthesis method utilizes carboxylic acids as raw material, which is stable, cheap, and commercially available. Scope studies show that this reaction has good compatibility of functional groups. Notably, both the synthesis of steric hindrance phosphorothioates and the later modification of some bioactive compounds are successfully achieved.

SCI

英语

NI论文

其他

National Natural Science Foundation[21772046,2193103] ; Natural Science Foundation of Fujian Province[2019J05095] ; Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University[ZQN-705] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]

Chemistry

Chemistry, Organic

WOS:000693633500025

AMER CHEMICAL SOC

CHEMISTRY

2-s2.0-85114425576

Scopus

1.Institute of Next Generation Matter Transformation,College of Material Sciences Engineering,Huaqiao University,Xiamen,668 Jimei Boulevard, Fujian,361021,China
2.Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Guo，Yu,Luo，Ying,Mu，Shiqiang,et al. Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters[J]. ORGANIC LETTERS,2021,23(17).

Guo，Yu,Luo，Ying,Mu，Shiqiang,Xu，Jian,&Song，Qiuling.(2021).Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters.ORGANIC LETTERS,23(17).

Guo，Yu,et al."Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters".ORGANIC LETTERS 23.17(2021).