Fabrication, Characterization and Performance Evaluation of Screen-printed Carbon Electrodes: Determination of Acetaminophen in Tylenol

MA，Lu Lu1,2,3; HE，Yi4; QIN，Da5; CHANG，Anthony4; HUANG，Alexander4; XIE，Xiao Jiang6; ZHENG，Yan2,3

2021-09-01

10.1016/S1872-2040(21)60116-0

Chinese Journal of Analytical Chemistry   影响因子和分区

1872-2040

Screen-printed carbon electrodes (SPCEs) were fabricated and compared with the commercial DS 110 (DropSens). In addition to the classic cyclic voltammetry (CV) of K[Fe(CN)], a method using widely available Bausch + Lomb and Tylenol was developed for comprehensive evaluation of the electrochemical performance of SPCEs. Scanning electron microscope (SEM) images showed that the graphite surface of the in-house SPCEs, which acted as reaction surface, was covered by grainy binders thus less reactive than DS 110. X-ray photoelectron (XPS) spectra indicated that both were composed primarily of graphite (> 85%), but the concentrations of S (detected in DS110 only), N and Cl in the less-electroactive binders differed. The CV using K[Fe(CN)] as probe revealed that the peak-to-peak separation of the in-house SPCE (0.140 V) was further apart than that of DS 110 (0.075 V). The oxidation and reduction peak currents of the in-house SPCE were 73% and 82% of that of the DS 110, respectively. When CV was applied to the determination of acetaminophen in Tylenol (product label concentration: 661 mmol/L) using Bausch + Lomb solution with 1 mol/L KCl as the buffer, DS 110 showed better sensitivity, but the in-house SPCE was stable and more precise. Though DS 110 displayed higher current and thus more sensitive, the in-house SPCE current was stable and thus more precise. The concentrations obtained from oxidation and reduction peaks were (775 ± 80) mmol/L and (686 ± 322) mmol/L for DS 110, and (637 ± 39) mmol/L and (713 ± 139) mmol/L for in-house SPCE, respectively. Moreover, DS 110 exhibited two large unknown peaks and thus less reliable in the acetaminophen-in-Tylenol CV test. Determination of acetaminophen in real Tylenol sample was helpful as additional quality control in SPCEs fabrication.

Acetaminophen Bausch + Lomb multi-purpose solution Screen-printed carbon electrode Tylenol

SCI ; EI

英语

第一 ; 通讯

WOS:000694942100004

20213710891213

Binders ; Cyclic voltammetry ; Electrodes ; Fabrication ; Graphite ; Iron compounds ; Photoelectron spectroscopy ; Potassium compounds ; Reduction ; Scanning electron microscopy ; Surface reactions

Electrochemistry:801.4.1 ; Chemical Reactions:802.2 ; Chemical Agents and Basic Industrial Chemicals:803 ; Quality Assurance and Control:913.3

CHEMISTRY

2-s2.0-85114692374

Scopus

1.CAcademy for Advanced Interdisciplinary Studies,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China
2.State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China
3.Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China
4.Department of Sciences,John Jay College,the City University of New York,New York,10019,United States
5.Institute of Forensic Science,Ministry of Public Security,Beijing,100038,China
6.Department of Chemistry,Southern University of Science and Technology (SUSTech),Shenzhen,518055,China

MA，Lu Lu,HE，Yi,QIN，Da,et al. Fabrication, Characterization and Performance Evaluation of Screen-printed Carbon Electrodes: Determination of Acetaminophen in Tylenol[J]. Chinese Journal of Analytical Chemistry,2021,49(9):e21187-e21196.

MA，Lu Lu.,HE，Yi.,QIN，Da.,CHANG，Anthony.,HUANG，Alexander.,...&ZHENG，Yan.(2021).Fabrication, Characterization and Performance Evaluation of Screen-printed Carbon Electrodes: Determination of Acetaminophen in Tylenol.Chinese Journal of Analytical Chemistry,49(9),e21187-e21196.

MA，Lu Lu,et al."Fabrication, Characterization and Performance Evaluation of Screen-printed Carbon Electrodes: Determination of Acetaminophen in Tylenol".Chinese Journal of Analytical Chemistry 49.9(2021):e21187-e21196.