The Second Filter's Second Coming

Ramamoorthy, Sripriya1; Chen, Fangyi1,2; Zha, Dingjun1,3; Jacques, Steven L.1; Wang, Ruikang4; Choudhoury, Niloy1; Nuttall, Alfred L.1; Fridberger, Anders1,5

10.1063/1.4939337

2015

0094-243X

MECHANICS OF HEARING: PROTEIN TO PERCEPTION

1703

2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA

AMER INST PHYSICS

We measured sound-evoked vibrations at the stereociliary side of inner and outer hair cells and their surrounding supporting cells, using optical coherence tomography interferometry in living anesthetized guinea pigs. Our measurements demonstrate a gradient in frequency tuning among different cell types, going from a high best frequency at the inner hair cells to a lower one at the Hensen cells. This causes the locus of maximum inner hair cell activation to be shifted toward the apex of the cochlea as compared to the outer hair cells. These observations show that additional processing and filtering of acoustic signals occurs within the organ of Corti prior to inner hair cell excitation, thus reinstating a transformed second filter as a mechanism contributing to cochlear frequency tuning.

其他

英语

CPCI-S

Biochemistry & Molecular Biology ; Biophysics ; Otorhinolaryngology

Biochemistry & Molecular Biology ; Biophysics ; Otorhinolaryngology

WOS:000372065400024

Web of Science

1.Oregon Hlth & Sci Univ, Portland, OR 97201 USA
2.South Univ Sci & Technol China, Guangdong, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Peoples R China
4.Univ Washington, Seattle, WA 98195 USA
5.Linkoping Univ, Linkoping, Sweden

Ramamoorthy, Sripriya,Chen, Fangyi,Zha, Dingjun,et al. The Second Filter's Second Coming[C]. 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA:AMER INST PHYSICS,2015.