Surfactant-free electrochemical synthesis of fluoridated hydroxyapatite nanorods for biomedical applications

Ge, Xiang1,2; Ren, Chengzu1; Lu, Xiong3; Li, Zhaoyang4; Chen, Guang1; Wang, Kefeng5; Ren, Fuzeng6; Wang, Qun7; Wang, Menghao3; An, Xinxin8; Qian, Bao9

2019-10

10.1016/j.ceramint.2019.05.292

CERAMICS INTERNATIONAL   影响因子和分区

0272-8842

1873-3956

Fluoridated hydroxyapatite (FHA) [Ca-10(PO4)(6)FxOH)(2-x) x = 0-2] is believed to be a promising calcium phosphate (CaP) to replace pure hydroxyapatite (HA) for next-generation implants, owing to its better biocompatibility, higher antibacterial activity, and lower solubility. Notably, the shape and size of the CaP crystals play key roles in their performance and can influence their applications. One-dimensional (1D) FHA nanorods are important CaP materials which have been widely used in regenerative medicine applications such as restorative dentistry. Unfortunately, the traditional synthesis methods for FHA nanorods either employ surfactants or take a relatively long time. In this study, we aimed to propose a facile synthesis route to fabricate FHA nanorods without any surfactants using an electrochemical deposition method for the first time. This study focused on preparing FHA nanorods without the assistance of any surfactant, unlike the traditional synthesis methods, to avoid chemical impurities. FHA nanorods with lengths of 124-2606 nm, diameters of 28-211 nm, and aspect ratios of 4.4-21.8 were synthesized using the electrochemical method, followed by a heat treatment. For the as-synthesized FHA nanorods, the Ca/P ratio was 1.60 and the atomic concentration of F was 2.06 at.%. An ultrastructure examination revealed that each FHA nanorod possessed long-range order, good crystallinity, and a defect-free lattice with a certain crystallographic plane orientation along the whole rod. In short, we propose a novel, surfactant-free, cost-saving, and more efficient route to synthesize FHA nanorods which can be widely applied in multiple biomedical applications, including drug delivery, bone repair, and restorative dentistry.

Surfactant-free Electrochemical Fluoridated hydroxyapatite (FHA) Nanorods Transmission electron microscopy (TEM) High resolution TEM (HRTEM)

SCI ; EI

英语

其他

Research Grants Council of Hong Kong[HKUST615408]

Materials Science

Materials Science, Ceramics

WOS:000482244200078

ELSEVIER SCI LTD

20192307008164

Aspect ratio ; Biocompatibility ; Calcium phosphate ; Crystal impurities ; Crystallinity ; Dentistry ; Drug delivery ; Electrochemical deposition ; High resolution transmission electron microscopy ; Hydroxyapatite ; Medical applications ; Reduction ; Surface active agents ; Transmission electron microscopy

Immunology:461.9.1 ; Optical Devices and Systems:741.3 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Chemical Agents and Basic Industrial Chemicals:803 ; Inorganic Compounds:804.2 ; Solid State Physics:933 ; Crystal Lattice:933.1.1

MATERIALS SCIENCE

Web of Science

1.Tianjin Univ, Sch Mech Engn, Key Lab Mech Theory & Equipment Design, Minist Educ, Tianjin 300354, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
3.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China
4.Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300354, Peoples R China
5.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
6.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
7.MianYang Teachers Coll, Coll Life Sci & Biotechnol, Mianyang 621006, Sichuan, Peoples R China
8.Tianjin Agr Univ, Sch Humanities, Tianjin 300384, Peoples R China
9.Univ Kassel, Dept Machine Elements & Engn Design, D-34125 Kassel, Germany

Ge, Xiang,Ren, Chengzu,Lu, Xiong,et al. Surfactant-free electrochemical synthesis of fluoridated hydroxyapatite nanorods for biomedical applications[J]. CERAMICS INTERNATIONAL,2019,45(14):17336-17343.

Ge, Xiang.,Ren, Chengzu.,Lu, Xiong.,Li, Zhaoyang.,Chen, Guang.,...&Qian, Bao.(2019).Surfactant-free electrochemical synthesis of fluoridated hydroxyapatite nanorods for biomedical applications.CERAMICS INTERNATIONAL,45(14),17336-17343.

Ge, Xiang,et al."Surfactant-free electrochemical synthesis of fluoridated hydroxyapatite nanorods for biomedical applications".CERAMICS INTERNATIONAL 45.14(2019):17336-17343.