Microfluidic Synthesis of Gd-Based Nanoparticles for Fast and Ultralong MRI Signals in the Solid Tumor

Li, Xuanyu1,2,3; Feng, Qiang1,2,3; Jiang, Xingyu1,2,3,4

2019-09-17

10.1002/adhm.201900672

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Clinically used magnetic resonance imaging contrast agents (MRI CAs) for solid tumors suffer from short life spans and low accumulation at the tumor for their low molecular weights. A good solution is to incorporate these MRI CAs into nanoparticles. Food and Drug Administration-approved compounds, poly(lactic-co-glycolic acid) (PLGA) and lipids, are chosen to assemble these nanoparticles. PLGA/lipid hybrid nanoparticles are assembled in microfluidic channels with a suitable size distribution for imaging tumors. These nanoparticles achieve clearly enhanced MRI contrast at the tumor at 0.5 h postinjection. The enhanced MRI contrast is sustained for 16 h. They can margin the tumor with as good an enhanced MRI contrast as clinical MRI CAs (which visualize the whole tumor) of the solid tumor with much less Gd. They are particularly useful for monitoring the solid tumor after therapy within a day and without repeated administration as clinical MRI CAs.

microfluidics MRI nanoparticles tumors

SCI ; EI

英语

通讯

Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Chinese Academy of Sciences[121D11KYSB20170026] ; Chinese Academy of Sciences[XDA16020902]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000486898300001

WILEY

20194407591731

Drug delivery ; Magnetic resonance imaging ; Microfluidics ; Nanoparticles ; Signal systems ; Synthesis (chemical) ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Microfluidics:632.5.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Solid State Physics:933

Web of Science

1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, CAS Ctr Excellence Nanosci, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
2.Natl Ctr NanoSci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Li, Xuanyu,Feng, Qiang,Jiang, Xingyu. Microfluidic Synthesis of Gd-Based Nanoparticles for Fast and Ultralong MRI Signals in the Solid Tumor[J]. Advanced Healthcare Materials,2019,8(20).

Li, Xuanyu,Feng, Qiang,&Jiang, Xingyu.(2019).Microfluidic Synthesis of Gd-Based Nanoparticles for Fast and Ultralong MRI Signals in the Solid Tumor.Advanced Healthcare Materials,8(20).

Li, Xuanyu,et al."Microfluidic Synthesis of Gd-Based Nanoparticles for Fast and Ultralong MRI Signals in the Solid Tumor".Advanced Healthcare Materials 8.20(2019).