Directional assembly of a stapled alpha-helical peptide

Hu, Kuan1; Yin, Feng1; Zhou, Ziyuan1,2; Lian, Chenshan1; Liu, Yinghuan1; Sun, Chengjie1; Li, Wenjun1; Zhang, Jianing1; Li, Zigang1

2019-09-11

10.1039/c9cc04591k

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

The de novo design of stapled peptide-based self-assemblies attracts vast interest, yet still remains challenging. The development of an oxidation trigger for peptide stapling and subsequent self-assembly is described here. A self-assembling sequence, Fmoc-R(RCEX)(2)-NH2, transformed from a random coil to an alpha-helical structure upon disulphide bonding of the flanking cysteine residues positioning at the i/i + 4 locations. The stapling form of this peptide enforces a conformational restraint that affords the driving force for self-assembly into nanorod/nanovesicle structures. Moreover, these assembled materials can transport siRNA into cancer cells and immediately release the cargo in a reductive environment.

SCI ; EI

英语

NI论文

其他

Shenzhen Science and Technology Innovation Committee[JCYJ20170412150719814]

Chemistry

Chemistry, Multidisciplinary

WOS:000482853900027

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3, Dept Infect Dis, Shenzhen 518112, Peoples R China

Hu, Kuan,Yin, Feng,Zhou, Ziyuan,et al. Directional assembly of a stapled alpha-helical peptide[J]. CHEMICAL COMMUNICATIONS,2019,55(70):10484-10487.

Hu, Kuan.,Yin, Feng.,Zhou, Ziyuan.,Lian, Chenshan.,Liu, Yinghuan.,...&Li, Zigang.(2019).Directional assembly of a stapled alpha-helical peptide.CHEMICAL COMMUNICATIONS,55(70),10484-10487.

Hu, Kuan,et al."Directional assembly of a stapled alpha-helical peptide".CHEMICAL COMMUNICATIONS 55.70(2019):10484-10487.