南方科技大学知识苑(SUSTech KC): Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters

题名	Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters
作者	Chen, Diao 1; Liu, Jian-Guo2,3 ; Zhang, Xu 1; Xu, Ming-Hua1,2,3
通讯作者	Xu, Ming-Hua
发表日期	2019-09-03
DOI	10.1055/s-0037-1610722
发表期刊	SYNLETT 影响因子和分区
ISSN	0936-5214
EISSN	1437-2096
卷号	30 期号:14页码:1693-1697
摘要	A rhodium-catalyzed enantioselective addition of glyoxylates to arylboronic acids promoted by a simple chiral sulfinamide-based olefin ligand under mild reaction conditions is described. The reaction provides access to a variety of optically active substituted mandelic acid esters in good yields with up to 83% ee. The catalytic system is also applicable to pyruvate addition. The synthetic utility of this method is highlighted by a formal synthesis of the antiplatelet drug clopidogrel.
关键词	asymmetric catalysis rhodium catalysis ligands mandelic acid esters glyoxylate arylboronic acids
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
学校署名	通讯
资助项目	National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[21472205] ; National Natural Science Foundation of China[21325209]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000481808000014
出版者	GEORG THIEME VERLAG KG
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25212
专题	深圳格拉布斯研究院理学院_化学系
作者单位	1.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
通讯作者单位	深圳格拉布斯研究院; 化学系
推荐引用方式 GB/T 7714	Chen, Diao,Liu, Jian-Guo,Zhang, Xu,et al. Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters[J]. SYNLETT,2019,30(14):1693-1697.
APA	Chen, Diao,Liu, Jian-Guo,Zhang, Xu,&Xu, Ming-Hua.(2019).Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters.SYNLETT,30(14),1693-1697.
MLA	Chen, Diao,et al."Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters".SYNLETT 30.14(2019):1693-1697.