Multifunctional iron-based Metal - Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy

Ma, Xiaoyan1,2; Ren, Xiangling1; Guo, Xudong2; Fu, Changhui1; Wu, Qiong1; Tan, Longfei1; Li, Hongbo3; Zhang, Wei4,5; Chen, Xudong4,5; Zhong, Hongshan6; Meng, Xianwei1

2019-09

10.1016/j.biomaterials.2019.119223

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Nanozymes with excellent enzyme-mimicking catalytic property are playing an increasingly significant role in tumor diagnosis and therapy. Fe-metal organic framework nanoparticles (MIL-101(Fe) NPs) are prepared as nanozymes to generate reactive oxygen species (ROS) and induce cancer cell death by catalyzing endogenous substances in tumor microenvironment. Abundant stimuli-responsive hydroxyl radicals (center dot OH) are accelerated to generate in the presence of microwave irradiation, realizing microwave enhancing dynamic therapy (MEDT). Moreover, MIL-101(Fe) NPs possess biodegradability and bioresponsibility, which exhibit favourable properties of metabolism and non-toxic accumulation comparing with inorganic nanozymes. Fluorescent gold nanodusters (BSA-Au NCs) are rapidly coupled with the surface of MIL-101(Fe) NPs to obtain MIL-101(Fe)@BSA-AuNCs NPs. MIL-101(Fe)@BSA-AuNCs NPs with magnetic resonance imaging (MRI) and fluorescent imaging (FI) not only image accurately for the site of tumor, but also monitor dynamic distribution process of MIL-101(Fe) in vivo. The signal intensity of FI and MRI reaches maximum at 1 h in the liver and 5 h in the tumor. Ionic liquid (IL) is also loaded into MIL-101(Fe)@BSA-AuNCs NPs as microwave sensitive reagents for microwave thermal therapy (MTT). This work synthesizes the nanozymes that possess degradability, microwave sensitivity and dual-mode imaging to achieve the combination of MTT and MEDT against tumor. Experiment result in vivo confirms that the kill rate of tumor is up to 96.65%, showing an outstanding anti-tumor efficacy.

Nanozyme Metal-organic framework Enzyme mimics Microwave Cancer therapy

SCI ; EI

英语

其他

Beijing Natural Science Foundation[4161003]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000473121700007

ELSEVIER SCI LTD

20192407047728

Biodegradability ; Cell death ; Crystalline materials ; Diagnosis ; Diseases ; Enzymes ; Fluorescence imaging ; Gold compounds ; Ionic liquids ; Iron ; Magnetic resonance imaging ; Metal nanoparticles ; Microwave irradiation ; Microwaves ; Nanoclusters ; Organometallics ; Tumors

Bioengineering and Biology:461 ; Iron:545.1 ; Electromagnetic Waves:711 ; Imaging Techniques:746 ; Nanotechnology:761 ; Biochemistry:801.2 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Crystalline Solids:933.1

MATERIALS SCIENCE

Web of Science

1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Cryogen, Lab Controllable Preparat & Applicat Nanomat, 29 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Inner Mongolia Univ, State Key Lab Reprod Regulat & Breeding Grassland, 24 Zhaojun Rd, Hohhot 010070, Peoples R China
3.Beijing Inst Technol, Sch Mat Sci & Engn, Beijing Key Lab Construct Tailorable Adv Funct Ma, Beijing 100081, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
5.Shenzhen Intervent Med Engn Res & Dev Ctr, Shenzhen 518020, Peoples R China
6.China Med Univ, Hosp 1, Dept Radiol, Shenyang 110001, Liaoning, Peoples R China

Ma, Xiaoyan,Ren, Xiangling,Guo, Xudong,et al. Multifunctional iron-based Metal - Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy[J]. BIOMATERIALS,2019,214.

Ma, Xiaoyan.,Ren, Xiangling.,Guo, Xudong.,Fu, Changhui.,Wu, Qiong.,...&Meng, Xianwei.(2019).Multifunctional iron-based Metal - Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy.BIOMATERIALS,214.

Ma, Xiaoyan,et al."Multifunctional iron-based Metal - Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy".BIOMATERIALS 214(2019).