Quantitative investigation of vascular response to mesenteric venous thrombosis using large-field-of-view photoacoustic microscopy

Qin, Wei; Qi, Weizhi; Xi, Lei

2019-08-21

10.1002/jbio.201900198

Journal of Biophotonics   影响因子和分区

1864-063X

1864-0648

Mesenteric venous thrombosis (MVT) is one of major causes leading to severe mesenteric ischemia. Vascular network plays an important role during the occurrence and development of MVT. However, there lacks an appropriate imaging method, which features advanced volumetric resolving capability, superior sensitivity to hemoglobin, and ultra-large field-of-view (FOV), to investigate vascular response of MVT. In this study, we developed and applied a large-FOV optical resolution photoacoustic microscopy to quantify the vascular response during the entire course of two different MVT models in which we ligated the superior mesenteric vein and inferior mesenteric vein, respectively. Furthermore, we developed a quantitative algorithm to derive total vascular length, relative concentration of total hemoglobin and vascular density over the FOV to reveal different vascular responses in different MVT models.

mesenteric venous thrombosis optical resolution photoacoustic microscopy urinary volatile organic compounds

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[61775028] ; National Natural Science Foundation of China[61528401] ; National Natural Science Foundation of China[81571722]

Biochemistry & Molecular Biology ; Biophysics ; Optics

Biochemical Research Methods ; Biophysics ; Optics

WOS:000482858400001

WILEY-V C H VERLAG GMBH

20193407349802

Blood vessels ; Diseases ; Hemoglobin ; Volatile organic compounds

Biological Materials and Tissue Engineering:461.2 ; Imaging Techniques:746 ; Organic Compounds:804.1

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Qin, Wei,Qi, Weizhi,Xi, Lei. Quantitative investigation of vascular response to mesenteric venous thrombosis using large-field-of-view photoacoustic microscopy[J]. Journal of Biophotonics,2019,12(12).

Qin, Wei,Qi, Weizhi,&Xi, Lei.(2019).Quantitative investigation of vascular response to mesenteric venous thrombosis using large-field-of-view photoacoustic microscopy.Journal of Biophotonics,12(12).

Qin, Wei,et al."Quantitative investigation of vascular response to mesenteric venous thrombosis using large-field-of-view photoacoustic microscopy".Journal of Biophotonics 12.12(2019).