Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation

Wang, Zhenming1,2,3; Zhao, Fin1,2; Tang, Wanze1,2; Hu, Liqiu1,2; Chen, Xin1,2; Su, Yiping4; Zou, Chang5; Wang, Jianhong5; Lu, William W.6; Zhen, Wanxin1,2; Zhang, Ronghua3,7; Yang, Dazhi1,2; Peng, Songlin1,2,5

2019-08-18

10.1002/smll.201901560

Small   影响因子和分区

1613-6810

1613-6829

Tissue-engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone-tissue regeneration.

biomimetic mineralization bone-tissue engineering black phosphorus nanosheets ECM microenvironment high-strength nanoengineered hydrogels

SCI ; EI

英语

其他

Shenzhen Municipal Science and Technology Innovation Committee Project[JCYJ20180305164659637] ; Shenzhen Municipal Science and Technology Innovation Committee Project[JSGG20180504170427135] ; Shenzhen Municipal Science and Technology Innovation Committee Project[JCYJ20160229172757249] ; Shenzhen Municipal Science and Technology Innovation Committee Project[JCYJ20160301151248779] ; Shenzhen Municipal Science and Technology Innovation Committee Project[JCYJ20170413162104773]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000481805900001

WILEY-V C H VERLAG GMBH

20193407338512

Biomechanics ; Biomimetics ; Bone ; Calcium compounds ; Hydrogels ; Mechanical properties ; Mineralogy ; Nanosheets ; Phosphorus ; Tissue

Bioengineering and Biology:461 ; Mineralogy:482 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Solid State Physics:933 ; Materials Science:951

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Spine Surg, Shenzhen 518020, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Inst Orthopaed Res, Shenzhen 518020, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
5.Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen 519020, Peoples R China
6.Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong 999077, Peoples R China
7.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

Wang, Zhenming,Zhao, Fin,Tang, Wanze,et al. Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation[J]. Small,2019,15(41).

Wang, Zhenming.,Zhao, Fin.,Tang, Wanze.,Hu, Liqiu.,Chen, Xin.,...&Peng, Songlin.(2019).Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation.Small,15(41).

Wang, Zhenming,et al."Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation".Small 15.41(2019).