Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3

Zhang, Jinling1; Song, Huibin2,3; Chen, Chen2,4; Chen, Lipeng2; Dai, Yong2; Sun, Ping-Hui2; Zou, Chang2,5,6; Wang, Xiaoyu7

2021-10-01

10.1016/j.phrs.2021.105814

PHARMACOLOGICAL RESEARCH   影响因子和分区

1043-6618

1096-1186

Cervical cancer is one of the common malignancies in women, which is characterized with high invasion and metastatic tendency in its advanced stage. Increasing evidence indicates that methyltransferase-like (METTL) gene family is involved in the progression of various cancers. However, the functional role of methyltransferase-like gene family in cervical cancer remains unclear. In the present study, we found that METTL11A, a member of the methyltransferase-like gene family, was significantly over-expressed in cervical carcinoma by analyzing TCGA database. This finding was further validated in clinical tissue samples. Moreover, ectopic expression of METTL11A in cervical cancer cell lines promoted cell proliferation and migration both in vitro and in vivo. Differential gene expression analysis in the transcriptomic sequencing data indicated that ELK3 was downregulated in METTL11A-silenced cervical cancer cells, which was further verified at both protein and mRNA levels. Functional experiments identified that METTL11A promoted migration of cervical cancer cells in an ELK3-dependent manner. This study will promote understanding the mechanism of cervical cancer progression and the functional role of methyltransferase-like gene families in cancers.

METTL11A ELK3 Cervical cancer Cell proliferation Cell migration

SCI

英语

通讯

Guangdong Basic and Applied Basic Research Foundation[2020B1515120032] ; Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis, The Shenzhen Economic and Information Committee "Innovation Chain and Industry Chain" integration special support plan project[20180225112449943] ; Shenzhen Key Medical Discipline Construction Fund[SZXK053] ; Guangdong Provincial Natural Science Foundation[2018A030313743]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000696677900024

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Dept Gynaecol, Clin Med Coll 2, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Dept Clin Med Res Ctr, Clin Med Coll 2, Shenzhen Peoples Hosp,Jinan Univ,Affiliated Hosp, Shenzhen, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou, Guangdong, Peoples R China
4.Guangdong Med Univ, China Amer Canc Res Inst, Dongguan Key Lab Epigenet, Dongguan, Peoples R China
5.Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen 518172, Guangdong, Peoples R China
6.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Clin Med Coll 2, Shenzhen, Peoples R China
7.Jinan Univ, Dept Gynaecol, Affiliated Hosp 1, Guangzhou, Peoples R China

Zhang, Jinling,Song, Huibin,Chen, Chen,et al. Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3[J]. PHARMACOLOGICAL RESEARCH,2021,172.

Zhang, Jinling.,Song, Huibin.,Chen, Chen.,Chen, Lipeng.,Dai, Yong.,...&Wang, Xiaoyu.(2021).Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3.PHARMACOLOGICAL RESEARCH,172.

Zhang, Jinling,et al."Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3".PHARMACOLOGICAL RESEARCH 172(2021).