Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction

Fang, Wei1; Zhang, Yu1; Li, Sinian1; Liu, Aiming2; Jiang, Yin2; Chen, Dandan1; Li, Binbin3; Yao, Can3; Chen, Rongchang1; Shi, Fei3

2021

10.2147/JAA.S328652

Journal of Asthma and Allergy   影响因子和分区

1178-6965

["Background: Reversible airflow obstruction (RO) and fixed airflow obstruction (FO) are two important clinical phenotypes of asthma. However, the relationship between air pollutant exposure and exacerbation of the two phenotypes is unknown.","Objective: To study the effects of air pollutant exposure on exacerbation severity in asthma patients with or without FO.","Methods: A total of 197 severe asthma patients were enrolled, and divided into two groups: the FO group (n=81) and the RO group (n=116). We collected the demographic data, laboratory parameters, pulmonary function test parameters, and the daily average concentrations of different air particles in Shenzhen on the different lag days of each subject. The receiver operating characteristic (ROC) curve was used to identify the effects of major air pollutants on the severity of asthma patients with RO.","Results: Compared with the RO group, the FO group had fewer women, lower body mass index (BMI), longer disease duration, higher smoking history rate, allergic family history rate, FeNO level, and lower levels of large airway parameters. The median exposure levels of PM10 and PM2.5 in the severe RO subgroup were both higher than those in the mild-to-moderate RO subgroup on Lag0, 1 and 3, and the median exposure level of PM1 on Lag0 in the severe RO subgroup was significantly higher than that in the mild-to-moderate RO subgroup. Logistic regression modeling indicated exposure to PM2.5 and PM1.0 on Lag0, and PM10 on Lag0-2 were the independent risk factors for hospital admissions for asthma patients with RO. By performing an ROC curve analysis, PM2.5 on Lag0 (AUC = 0.645, p = 0.027) provided a best performance to predict severe asthma exacerbations with RO, with a sensitivity of 36.0% and a specificity of 91.2%.","Conclusion: Short-term exposure to PM10, PM2.5 and PM1 may play a role in exacerbation severity among asthma patients with RO."]

air particles asthma reversible airflow obstruction fixed airflow obstruction

SCI

英语

第一 ; 通讯

Natural Science Foundation of Guangdong Province, China[2020A151501040] ; Natural Science Foundation of China[81300012] ; Appropriate Health Technology Promotion Project of Guangdong Province[2020181]

Allergy ; Immunology ; Respiratory System

Allergy ; Immunology ; Respiratory System

WOS:000701657300001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2,Key Lab Shenzhen Resp Dis, Affiliated Hosp 1,Shenzhen Peoples Hosp,Inst Shen, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Key Lab Severe Weather South China, Shenzhen Natl Climate Observ, Meteorol Bur Shenzhen Municipal, Shenzhen, Guangdong, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2,Emergency Dept, Affiliated Hosp 1,Shenzhen Peoples Hosp,Inst Shen, Shenzhen, Guangdong, Peoples R China

Fang, Wei,Zhang, Yu,Li, Sinian,et al. Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction[J]. Journal of Asthma and Allergy,2021,14.

Fang, Wei.,Zhang, Yu.,Li, Sinian.,Liu, Aiming.,Jiang, Yin.,...&Shi, Fei.(2021).Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction.Journal of Asthma and Allergy,14.

Fang, Wei,et al."Effects of Air Pollutant Exposure on Exacerbation Severity in Asthma Patients with or without Reversible Airflow Obstruction".Journal of Asthma and Allergy 14(2021).