Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis

Zhao, Juanjuan1,2,3; Shi, Jijing4; Qu, Mengmeng3; Zhao, Xin1,5; Wang, Hongbo6; Huang, Man1,2; Liu, Zhenwen6; Li, Zhiwei1,7; He, Qing1,2; Zhang, Shuye8,9; Zhang, Zheng1,2,10,11,12

2019-08-13

10.3389/fimmu.2019.01915

Frontiers in Immunology   影响因子和分区

1664-3224

Objectives: Liver cirrhosis (LC) is usually accompanied by cirrhosis associated immune dysfunction (CAID), including reduced naive T cells and memory B cells. However, little is known regarding on follicular helper T (Tfh) cell compartments in cirrhotic patients, especially in the secondary lymphoid organs such as spleen. This study characterizes splenic Tfh cells and explores its association with humoral immunity and disease progression in cirrhotic patients.

liver cirrhosis cirrhosis associated-immune dysfunction Tfh cell humoral immunity spleen

SCI

英语

第一 ; 通讯

National Program on Key Basic Research Project[2015CB554300]

Immunology

Immunology

WOS:000480549300002

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Peoples R China
2.Shenzhen Third Peoples Hosp, Inst Hepatol, Shenzhen, Peoples R China
3.Gen Hosp PLA, Med Ctr 5, Res Ctr Clin & Translat Med, Beijing, Peoples R China
4.First Peoples Hosp Zhengzhou, Cent Lab, Zhengzhou, Henan, Peoples R China
5.Gen Hosp PLA, Med Ctr 5, Dept Surg, Beijing, Peoples R China
6.Gen Hosp PLA, Med Ctr 5, Dept Liver Transplantat, Beijing, Peoples R China
7.Shenzhen Third Peoples Hosp, Dept Liver Transplantat, Shenzhen, Peoples R China
8.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
9.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
10.Shenzhen Third Peoples Hosp, Guangdong Key Lab Emerging Infect Dis, Shenzhen, Peoples R China
11.Guangzhou Med Univ, Sino French Hoffmann Inst, Sch Basic Med Sci, Key Lab Immunol, Guangzhou, Guangdong, Peoples R China
12.Guangzhou Med Univ, Affiliated Hosp 2, Guangdong Prov Key Lab Allergy & Clin Immunol, Guangzhou, Guangdong, Peoples R China

Zhao, Juanjuan,Shi, Jijing,Qu, Mengmeng,et al. Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis[J]. Frontiers in Immunology,2019,10.

Zhao, Juanjuan.,Shi, Jijing.,Qu, Mengmeng.,Zhao, Xin.,Wang, Hongbo.,...&Zhang, Zheng.(2019).Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis.Frontiers in Immunology,10.

Zhao, Juanjuan,et al."Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis".Frontiers in Immunology 10(2019).