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题名

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

作者
通讯作者Hofmann,Sandra
发表日期
2021-09-14
DOI
发表期刊
EISSN
2296-4185
卷号9
摘要

Mechanobiology research is for understanding the role of mechanics in cell physiology and pathology. It will have implications for studying bone physiology and pathology and to guide the strategy for regenerating both the structural and functional features of bone. Mechanobiological studies in vitro apply a dynamic micro-mechanical environment to cells via bioreactors. Porous scaffolds are commonly used for housing the cells in a three-dimensional (3D) culturing environment. Such scaffolds usually have different pore geometries (e.g. with different pore shapes, pore dimensions and porosities). These pore geometries can affect the internal micro-mechanical environment that the cells experience when loaded in the bioreactor. Therefore, to adjust the applied micro-mechanical environment on cells, researchers can tune either the applied load and/or the design of the scaffold pore geometries. This review will provide information on how the micro-mechanical environment (e.g. fluid-induced wall shear stress and mechanical strain) is affected by various scaffold pore geometries within different bioreactors. It shall allow researchers to estimate/quantify the micro-mechanical environment according to the already known pore geometry information, or to find a suitable pore geometry according to the desirable micro-mechanical environment to be applied. Finally, as future work, artificial intelligent – assisted techniques, which can achieve an automatic design of solid porous scaffold geometry for tuning/optimising the micro-mechanical environment are suggested.

关键词
相关链接[Scopus记录]
收录类别
SCI ; EI
语种
英语
学校署名
其他
WOS记录号
WOS:000704139800001
EI入藏号
20214010968673
EI主题词
Bioconversion ; Bioreactors ; Bone ; Cell engineering ; Cells ; Cytology ; Geometry ; Scaffolds (biology) ; Shear stress
EI分类号
Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biotechnology:461.8 ; Biology:461.9 ; Biochemistry:801.2 ; Chemical Plants and Equipment:802.1 ; Chemical Reactions:802.2 ; Mathematics:921
Scopus记录号
2-s2.0-85115977964
来源库
Scopus
引用统计
被引频次[WOS]:19
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/253486
专题工学院_系统设计与智能制造学院
作者单位
1.Orthopaedic Biomechanics,Department of Biomedical Engineering,Eindhoven University of Technology,Eindhoven,Netherlands
2.Institute for Complex Molecular Systems (ICMS),Eindhoven University of Technology,Eindhoven,Netherlands
3.Zienkiewicz Centre for Computational Engineering,Faculty of Science and Engineering,Swansea University,Swansea,United Kingdom
4.School of System Design and Intelligent Manufacturing,Southern University of Science and Technology,Shenzhen,China
推荐引用方式
GB/T 7714
Zhao,Feihu,Xiong,Yi,Ito,Keita,et al. Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering[J]. Frontiers in Bioengineering and Biotechnology,2021,9.
APA
Zhao,Feihu,Xiong,Yi,Ito,Keita,van Rietbergen,Bert,&Hofmann,Sandra.(2021).Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering.Frontiers in Bioengineering and Biotechnology,9.
MLA
Zhao,Feihu,et al."Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering".Frontiers in Bioengineering and Biotechnology 9(2021).
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