Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation

Zhu, Yuchen1,2,6; Cao, Zhe1; Peng, Ying1; Hu, Liqiu1,4,5; Guney, Tankut6; Tang, Bin1,2,3

2019-08-07

10.1021/acsami.9b03030

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Poly(ether ether ketone) (PEEK) is a promising material in biomedical engineering due to its suitable mechanical properties and excellent chemical resistance and biocompatibility. However, the biological inertness of PEEK limits its applications. In this study, we developed a facile approach of immersion to generate a biocompatible and bioactive PEEK that induced osteodifferentiation. First, micro-pores on the surface of PEEK were introduced by concentrated sulfuric acid and subsequent water immersion, followed by the hydrothermal treatment to reduce residual sulfuric acid. Subsequently, the sulfonated PEEK surface was activated by the oxygen plasma treatment and then coated with a poly(dopamine) (PDA) layer by immersion into the dopamine solution. Finally, the tripeptide Arg-Gly-Asp (RGD) was integrated onto the PDA-coated surface of PEEK by immersion into the RGD peptide solution. The surface characteristics (physical chemistry and biological properties) and the ability to form bonelike apatite were systematically investigated by scanning electron microscopy, X-ray photoelectron spectroscopy, water contact angle analysis, the Archimedes' fluid saturation method, ellipsometry, a quartz crystal microbalance with dissipation monitoring, cell proliferation, real-time reverse transcription polymerase chain reaction analysis, alizarin red staining, immunocytochemistry staining, and simulated body fluid immersion. Collectively, the modified PEEK showed a significantly improved ability to promote cell proliferation, osteogenic differentiation, and bonelike apatite formation in vitro as compared to the PEEK control. These results demonstrate that combined facile surface modifications for PEEK enhance its bioactivity and biocompatibility, and induce osteodifferentiation. This study presents a strategy for broadening the use of PEEK in the application of orthopedic implants and could be industrially scalable in future.

poly(ether ether ketone) (PEEK) surface modification bioactivity biocompatibility osteodifferentiation

SCI ; EI

英语

第一 ; 通讯

Shenzhen Science and Technology Innovation Committee[JCYJ20160517160827379] ; Shenzhen Science and Technology Innovation Committee[JCYJ20170817111312887] ; Shenzhen Science and Technology Innovation Committee[GRCK 20160829195523424] ; Shenzhen Science and Technology Innovation Committee[ZDSYS20140509142721429]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000480498600002

AMER CHEMICAL SOC

20193507360662

Amines ; Apatite ; Bioactivity ; Biocompatibility ; Biomechanics ; Biomedical engineering ; Body fluids ; Cell proliferation ; Chemical analysis ; Contact angle ; Ketones ; Neurophysiology ; Physical chemistry ; Plasma applications ; Polymerase chain reaction ; Scanning electron microscopy ; Sulfuric acid ; Surface treatment ; X ray photoelectron spectroscopy

Bioengineering and Biology:461 ; Minerals:482.2 ; Biochemistry:801.2 ; Physical Chemistry:801.4 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Plasma Physics:932.3

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Coll Med 2,Dept Spine Surg, Shenzhen 518020, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Coll Med 2,Inst Orthopaed R, Shenzhen 518020, Peoples R China
6.Helmholtz Zentrum Munchen, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, D-81377 Munich, Germany

Zhu, Yuchen,Cao, Zhe,Peng, Ying,et al. Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation[J]. ACS Applied Materials & Interfaces,2019,11(31):27503-27511.

Zhu, Yuchen,Cao, Zhe,Peng, Ying,Hu, Liqiu,Guney, Tankut,&Tang, Bin.(2019).Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation.ACS Applied Materials & Interfaces,11(31),27503-27511.

Zhu, Yuchen,et al."Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation".ACS Applied Materials & Interfaces 11.31(2019):27503-27511.