南方科技大学知识苑(SUSTech KC): Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters

题名	Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters
作者	Luan, Yipeng 1; Huang, Anqi 1; Cheng, Yuyu2,3 ; Liu, Xiaohong 1; Li, Pengfei2,3 ; Li, Wenjun 1
通讯作者	Li, Pengfei; Li, Wenjun
发表日期	2019-08-06
DOI	10.1002/adsc.201900684
发表期刊	ADVANCED SYNTHESIS & CATALYSIS 影响因子和分区
ISSN	1615-4150
EISSN	1615-4169
卷号	361 期号:18页码:4208-4214
摘要	The thiourea catalyzed enantioselective Michael addition of 5H-oxazol-4-ones to 2-enoylpyridine N-oxides is described. Under mild conditions, a series of optically active pyridine N-oxides inlaid with oxazolone motif were obtained in high yields (62-99%) with excellent stereoselectivities (84->99% ee and >20:1 dr). Notably, the method offers a direct synthetic approach to enantioenriched pyridine N-oxides featured by vicinal oxygen-containing tetrasubstituted stereocenters.
关键词	Oxazolones 2-Enoylpyridine N-oxides Organocatalysis Michael addition Thiourea
相关链接	[来源记录]
收录类别	SCI ; IC
语种	英语
学校署名	通讯
资助项目	Shenzhen Innovation of Science and Technology Commission[JCYJ20170817110526264] ; Shenzhen Innovation of Science and Technology Commission[ZDSYS201802081843490]
WOS研究方向	Chemistry
WOS类目	Chemistry, Applied ; Chemistry, Organic
WOS记录号	WOS:000480064700001
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/25362
专题	理学院_化学系
作者单位	1.Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Shandong, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Key Lab Marine Archaea Geoom, Shenzhen 518055, Guangdong, Peoples R China
通讯作者单位	化学系; 南方科技大学
推荐引用方式 GB/T 7714	Luan, Yipeng,Huang, Anqi,Cheng, Yuyu,et al. Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters[J]. ADVANCED SYNTHESIS & CATALYSIS,2019,361(18):4208-4214.
APA	Luan, Yipeng,Huang, Anqi,Cheng, Yuyu,Liu, Xiaohong,Li, Pengfei,&Li, Wenjun.(2019).Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters.ADVANCED SYNTHESIS & CATALYSIS,361(18),4208-4214.
MLA	Luan, Yipeng,et al."Organocatalytic Enantioselective Michael Addition of Oxazolones to 2-Enoylpyridine N-Oxides for Assembling of Pyridine N-Oxides Featuring Vicinal Oxygen-containing Tetrasubstituted Stereocenters".ADVANCED SYNTHESIS & CATALYSIS 361.18(2019):4208-4214.