gamma-Alkylation of Alcohols Enabled by Visible-Light Induced 1,6-Hydrogen Atom Transfer

Site-selective remote alkylation of alcohol is attractive but challenging in organic synthesis. Herein, we report a novel visible-light mediated gamma-alkylation of alcohol derivatives via the formation of C-sp3-C-sp3 bond through C-sp3-H bond functionalization under mild conditions. The use of sulfamate esters enables the directed, otherwise rare 1,6-HAT to generate gamma-selective C-centered radical, which is complementary to delta-selective 1,5-HAT of alcohols. This redox-neutral protocol provides a general and operationally simple method to access gamma-alkylated alcohols.