Sex bias in alcohol research: A 20-year comparative study

Li, Mianhuan1,2,3; Qu, Yibo4,5; Zhong, Jiajun2,3; Che, Zhaodi2,3; Wang, Hua6; Xiao, Junjie7; Wang, Fei8; Xiao, Jia2,3

2021-10-01

10.1016/j.yfrne.2021.100939

FRONTIERS IN NEUROENDOCRINOLOGY   影响因子和分区

0091-3022

1095-6808

We aimed to assess the sex-inclusive and sex-based analysis bias in alcohol research for the past 20 years. Data were abstracted from 2988 original research articles published from 2000 through 2019 in 51 representative journals across 9 biomedical disciplines. An analysis in 5-year intervals revealed that the percentage of studies using participants of both sexes was significantly higher between 2015 and 2019 than between 2000 and 2014. When stratified, clinical studies showed a higher percentage of both-sex studies compared to basic studies using animals. The reasons for the use of single-sex cohorts mainly included insufficient participant numbers and misconceptions surrounding the hormonal variability of females. Implementation of the NIH SABV policy promoted the ratio of NIH-funded papers with sex-based analyses. In conclusion, sex bias in alcohol-related biomedical studies has improved over the past 20 years, particularly after the implementation of the SABV policy. Although clinical studies increasingly included sex-based analysis, basic studies were biased towards the use of males.

Alcohol research Sex bias Sex-based analysis Human study Animal study

SCI

英语

第一

National Natural Science Foundation of China[81970515] ; Guangdong Natural Science Funds for Distinguished Young Scholar["2019B151502013","2016A030306001"]

Endocrinology & Metabolism ; Neurosciences & Neurology

Endocrinology & Metabolism ; Neurosciences

WOS:000702826700001

ACADEMIC PRESS INC ELSEVIER SCIENCE

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Hosp Affiliated 2, Shenzhen, Peoples R China
2.Jinan Univ, Clin Med Res Inst, Affiliated Hosp 1, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China
3.Jinan Univ, Dept Metab & Bariatr Surg, Affiliated Hosp 1, Guangzhou 510632, Peoples R China
4.Jinan Univ, Guangdong Hongkong Macau Inst CNS Regenerat, Key Lab CNS Regenerat, Minist Educ, Guangzhou, Peoples R China
5.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Inst Liver Dis, Hefei, Peoples R China
7.Shanghai Univ, Sch Life Sci, Cardiac Regenerat & Ageing Lab, Shanghai, Peoples R China
8.Sun Yat Sen Univ, Div Gastroenterol, Affiliated Hosp 7, 628 Zhenyuan Rd, Shenzhen 518106, Peoples R China

Li, Mianhuan,Qu, Yibo,Zhong, Jiajun,et al. Sex bias in alcohol research: A 20-year comparative study[J]. FRONTIERS IN NEUROENDOCRINOLOGY,2021,63.

Li, Mianhuan.,Qu, Yibo.,Zhong, Jiajun.,Che, Zhaodi.,Wang, Hua.,...&Xiao, Jia.(2021).Sex bias in alcohol research: A 20-year comparative study.FRONTIERS IN NEUROENDOCRINOLOGY,63.

Li, Mianhuan,et al."Sex bias in alcohol research: A 20-year comparative study".FRONTIERS IN NEUROENDOCRINOLOGY 63(2021).