Variations of phthalate exposure and metabolism over three trimesters

Li, Jiufeng1; Xia, Wei2,3,4; Wu, Chuansha2,3,4; Zhao, Hongzhi1; Zhou, Yanqiu1; Wei, Juntong1; Ji, Fenfen1; Luan, Hemi5; Xu, Shunqing2,3,4; Cai, Zongwei1

2019-08

10.1016/j.envpol.2019.04.085

ENVIRONMENTAL POLLUTION   影响因子和分区

0269-7491

1873-6424

Maternal exposure to phthalates may cause some adverse health effects on both mother and fetus, but variations of phthalate exposure and metabolism during pregnancy have not been thoroughly characterized. A total of 946 participants were selected from a cohort study conducted in Wuhan between 2014 and 2015 through which they had provided a complete set of urine samples at three trimesters. Eight phthalate metabolites were analyzed in 2838 urine samples. Based on urinary concentrations, various parameters (i.e. phthalate metabolite concentrations, ratios of metabolites of bis(2-ethylhexyl) phthalate (DEHP) in DEHP, and percentages of individual metabolites in total phthalates) were compared over three visits. We observed that levels of phthalate metabolites showed a U-shaped trend across three trimesters. The significant variations in the ratios of DEHP metabolites indicated that the efficiency in metabolizing DEHP declined during pregnancy and less recent exposure occurred in mid-pregnancy. The changes of percentages of individual compound in total phthalates suggested the inconsistent pattern over trimesters. This longitudinal study found that the exposure pattern, exposure timing and metabolic susceptibility varied by trimesters, which suggests that urine samples should be collected at multiple time points and mothers should be especially careful in the early pregnancy. (C) 2019 Elsevier Ltd. All rights reserved.

Chinese pregnant women Repeated measurement analysis Variations Phthalate metabolism

SCI ; EI

英语

其他

Research Grants Council of Hong Kong[12304117] ; Research Grants Council of Hong Kong[C2014-14E]

Environmental Sciences & Ecology

Environmental Sciences

WOS:000474329700016

ELSEVIER SCI LTD

20192006918072

Biomolecules ; Body fluids ; Metabolism ; Metabolites ; Obstetrics

Bioengineering and Biology:461 ; Organic Compounds:804.1

ENVIRONMENT/ECOLOGY

Web of Science

1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Key Lab Environm & Hlth, Minist Educ,Sch Publ Hlth, Wuhan, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan, Hubei, Peoples R China
5.Southern Univ Sci & Technol, SUSTech Acad Adv Interdisciplinary Studies, 1088 Xueyuan Rd, Shenzhen, Peoples R China

Li, Jiufeng,Xia, Wei,Wu, Chuansha,et al. Variations of phthalate exposure and metabolism over three trimesters[J]. ENVIRONMENTAL POLLUTION,2019,251:137-145.

Li, Jiufeng.,Xia, Wei.,Wu, Chuansha.,Zhao, Hongzhi.,Zhou, Yanqiu.,...&Cai, Zongwei.(2019).Variations of phthalate exposure and metabolism over three trimesters.ENVIRONMENTAL POLLUTION,251,137-145.

Li, Jiufeng,et al."Variations of phthalate exposure and metabolism over three trimesters".ENVIRONMENTAL POLLUTION 251(2019):137-145.