| 题名 | A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy |
| 作者 | |
| 通讯作者 | Zhong, Keli; Jiang, Dazhen; Wu, Yiping |
| 发表日期 | 2021-09-21
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| DOI | |
| 发表期刊 | |
| ISSN | 2234-943X
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| 卷号 | 11 |
| 摘要 | Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H2O2. MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. Both in vitro and in vivo experiments indicate that the ZCM system is both safe and has excellent tumor inhibition properties. ZCM is a novel system for CO controlled release, with significant potential to improve future cancer therapy. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Natural Science Foundation of China[81901771]
; Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund[2019022]
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| WOS研究方向 | Oncology
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| WOS类目 | Oncology
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| WOS记录号 | WOS:000704460700001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：10
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/253932 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastrointestinal Surg,Affiliated Hosp 1,Jina, Shenzhen, Peoples R China 3.Wuhan Univ, Dept Ophthalmol, Zhongnan Hosp, Wuhan, Peoples R China 4.Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan, Peoples R China 5.Wuhan Univ, Hubei Canc Clin Study Ctr, Dept Radiat & Med Oncol, Hubei Key Lab Tumor Biol Behav,Zhongnan Hosp, Wuhan, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li, Yang,Liu, Zeming,Zeng, Weng,et al. A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy[J]. Frontiers in Oncology,2021,11.
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| APA |
Li, Yang.,Liu, Zeming.,Zeng, Weng.,Wang, Ziqi.,Liu, Chunping.,...&Wu, Yiping.(2021).A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy.Frontiers in Oncology,11.
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| MLA |
Li, Yang,et al."A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy".Frontiers in Oncology 11(2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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