Ellagic acid, a plant phenolic compound, activates cyclooxygenase-mediated prostaglandin production

Wang, Hui Rong1; Sui, Hao Chen2; Zhu, Bao Ting1,2

2019-08

10.3892/etm.2019.7667

Experimental and Therapeutic Medicine   影响因子和分区

1792-0981

1792-1015

In recent years, ellagic acid (EA), a naturally-occurring phenolic compound richly contained in some of the human food sources such as Longan and Litchi, was reported to have a number of biological effects. Based on our earlier 3D-QSAR/CoMFA models for cyclooxygenase (COX) I and II, we hypothesize that EA may have the potential to modulate the catalytic activity of COX enzymes, and this hypothesis is examined in the present study. The results from both in vitro and in vivo experiments show that EA is an activator of COX enzyme-catalyzed production of prostaglandin E2, a representative prostaglandin tested. Mechanistically, EA can activate the peroxidase active site of COX enzymes by serving as a co-substrate, presumably for the reduction of protoporphorin IX with Fe-IV inside. The effect of EA is abrogated by the co-presence of galangin, which is known to bind to COX's peroxidase active site and thereby blocks the effect of the reducing co-substrates. In view of the known physiological functions of COX enzymes in the body, it is suggested that some of the pharmacological and/or toxicological effects of EA may result from an increased production of certain prostaglandins and their related derivatives in the body.

ellagic acid cyclooxygenase peroxidase activity mechanism of catalytic activation

SCI

英语

第一 ; 通讯

Shenzhen Peacock Plan[KQTD2016053117035204]

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:000476605000019

SPANDIDOS PUBL LTD

Web of Science

1.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Univ Hong Kong, Sch Sci & Engn, 2001 Longxiang Rd, Shenzhen 518172, Guangdong, Peoples R China

Wang, Hui Rong,Sui, Hao Chen,Zhu, Bao Ting. Ellagic acid, a plant phenolic compound, activates cyclooxygenase-mediated prostaglandin production[J]. Experimental and Therapeutic Medicine,2019,18(2):987-996.

Wang, Hui Rong,Sui, Hao Chen,&Zhu, Bao Ting.(2019).Ellagic acid, a plant phenolic compound, activates cyclooxygenase-mediated prostaglandin production.Experimental and Therapeutic Medicine,18(2),987-996.

Wang, Hui Rong,et al."Ellagic acid, a plant phenolic compound, activates cyclooxygenase-mediated prostaglandin production".Experimental and Therapeutic Medicine 18.2(2019):987-996.