Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets

Liao, Chengzhu1; Li, Yuchao2; Tjong, Sie Chin3

2019-08

10.3390/nano9081102

Nanomaterials   影响因子和分区

2079-4991

2079-4991

Aliphatic polyesters such as poly(lactic acid) (PLA), polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) copolymers have been widely used as biomaterials for tissue engineering applications including: bone fixation devices, bone scaffolds, and wound dressings in orthopedics. However, biodegradable aliphatic polyesters are prone to bacterial infections due to the lack of antibacterial moieties in their macromolecular chains. In this respect, silver nanoparticles (AgNPs), graphene oxide (GO) sheets and AgNPs-GO hybrids can be used as reinforcing nanofillers for aliphatic polyesters in forming antimicrobial nanocomposites. However, polymeric matrix materials immobilize nanofillers to a large extent so that they cannot penetrate bacterial membrane into cytoplasm as in the case of colloidal nanoparticles or nanosheets. Accordingly, loaded GO sheets of aliphatic polyester nanocomposites have lost their antibacterial functions such as nanoknife cutting, blanket wrapping and membrane phospholipid extraction. In contrast, AgNPs fillers of polyester nanocomposites can release silver ions for destroying bacterial cells. Thus, AgNPs fillers are more effective than loaded GO sheets of polyester nanocomposiites in inhibiting bacterial infections. Aliphatic polyester nanocomposites with AgNPs and AgNPs-GO fillers are effective to kill multi-drug resistant bacteria that cause medical device-related infections.

scaffold antibacterial activity aliphatic polyester osteoblast cellular viability staphylococcus aureus Escherichia coli electrospinning graphene oxide silver nanoparticle

SCI

英语

第一 ; 通讯

Natural Science Foundation of Shandong Province, China[ZR2019MB053]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000483604500047

MDPI

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China
2.Liaocheng Univ, Dept Mat Sci & Engn, Liaocheng 252000, Shandong, Peoples R China
3.City Univ Hong Kong, Dept Phys, Kowloon, Tat Chee Ave, Hong Kong 999077, Peoples R China

Liao, Chengzhu,Li, Yuchao,Tjong, Sie Chin. Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets[J]. Nanomaterials,2019,9(8).

Liao, Chengzhu,Li, Yuchao,&Tjong, Sie Chin.(2019).Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets.Nanomaterials,9(8).

Liao, Chengzhu,et al."Antibacterial Activities of Aliphatic Polyester Nanocomposites with Silver Nanoparticles and/or Graphene Oxide Sheets".Nanomaterials 9.8(2019).