Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration

Chen, Yingqi1,2; Li, Cairong1,2,3; Wang, Zhenming4,5; Long, Jing1,2; Wang, Ruiqi1,2; Zhao, Jin4,5; Tang, Wanze4,5; Zhao, Yu6,7; Qin, Ling1,2,8; Peng, Songlin4,5; Lai, Yuxiao1,2,3

2021-12-01

10.1016/j.apmt.2021.101182

Applied Materials Today   影响因子和分区

2352-9407

The repair of critical-sized bone defects remains challenging. Natural polysaccharide-based hydrogels (NPHs) have shown great promise for facilitating bone defect healing, but limited by osteogenesis, mechanical strength and stability. Here we prepared a water-soluble methacrylic anhydride-co-phosphate modified chitosan (CSMAP) incorporated MgO nanoparticles to form a pergel, and followed by introduction of acrylamide to construct a double-network hydrogel (CSMAP-MgO). We found that Mg2+ released from CSMAP-MgO hydrogel in a stable and sustained manner in 30 days and the compressive strength was maintained and the compressive modulus was even enhanced during immersion in PBS for 28 days. Moreover, the CSMAP-MgO hydrogel was superior in promoting in vitro calcium phosphate deposition, MC3T3-E1 cell proliferation, osteogenic differentiation, and mineralization compared to Magnesium free groups. At 12 weeks post-implantation into a rat critical-sized calvarial defect, the CSMAP-MgO hydrogel promoted significantly more new bone formation compared to CSMAP and non-treated groups. Thus, the CSMAP-MgO hydrogel has great promising as a bone filling material. (C) 2021 Elsevier Ltd. All rights reserved.

Nanocomposite hydrogels Mechanical stability Phosphate-functionalized chitosan Bone regeneration

SCI ; EI

英语

通讯

National Natural Science Foundation of China[82022045] ; CAS Interdisciplinary Innovation Team[JCTD-2020-19] ; National Key R&D Program of China[2021YFE0202600] ; Shenzhen Double Chain Project for Innovation and Development Industry - Bureau of Industry and Information Technology of Shenzhen[201908141541] ; Key Laboratory of Health Informatics, Chinese Academy of Sciences,Chinese Postdoctoral Science Foundation[2018M631006] ; CAS-HK Joint Lab of Biomaterials[2018A030310670] ; Natural Science Foundation of Guangdong Province[2018A030310670]

Materials Science

Materials Science, Multidisciplinary

WOS:000702912600007

ELSEVIER

Web of Science

1.Chinese Acad Sci, Ctr Translat Med Res & Dev, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
2.Guangdong Engn Lab Biomat Addit Mfg, Guangzhou 518055, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Dept Spine Surg, Shenzhen Peoples Hosp, Coll Med 2,Affiliated Hosp 1,Jinan Univ, Shenzhen 518020, Peoples R China
5.Southern Univ Sci & Technol, Inst Orthopaed Res, Shenzhen Peoples Hosp, Coll Med 2,Affiliated Hosp 1,Jinan Univ, Shenzhen 518020, Peoples R China
6.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China
7.Chinese Acad Med Sci, Beijing 100730, Peoples R China
8.Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China

Chen, Yingqi,Li, Cairong,Wang, Zhenming,et al. Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration[J]. Applied Materials Today,2021,25.

Chen, Yingqi.,Li, Cairong.,Wang, Zhenming.,Long, Jing.,Wang, Ruiqi.,...&Lai, Yuxiao.(2021).Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration.Applied Materials Today,25.

Chen, Yingqi,et al."Self-assembled nanocomposite hydrogels enhanced by nanoparticles phosphonate-magnesium coordination for bone regeneration".Applied Materials Today 25(2021).