Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China

Liu，Bihu1; Wei，Bincai1,7; Mo，Meile1; Song，Yanye2; Tang，Chuanqiao3; Tang，Peng1; Guo，Xiaojing1; Tan，Chao1,4; Liu，Shun5; Huang，Dongping6; Qiu，Xiaoqiang1

2022-02-01

10.1016/j.chemosphere.2021.132468

CHEMOSPHERE   影响因子和分区

0045-6535

1879-1298

Background: Previous epidemiological studies have examined the associations between exposure to perfluoroalkyl substances (PFASs) and the risk of hypertensive disorders of pregnancy (HDP). However, these studies have drawn discrepant conclusions and have some limitations. Methods: A nested case-control study was conducted with the Guangxi Zhuang Birth Cohort (GZBC), a prospective, ongoing birth cohort that was implemented in Guangxi, China, in June 2015. Maternal serum concentrations of nine PFASs were measured using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS). The associations between PFAS exposure and the risk of HDP were assessed using logistic regression (single-exposure), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models. Results: A total of 136 HDP cases and 408 controls were enrolled in this study. In logistic regression models, perfluoroundecanoic acid (PFUnA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluorobutanesulfonic acid (PFBS) were positively associated with HDP, while perfluorohexane sulfonate (PFHxS) was inversely associated with HDP. In the BKMR analysis, the joint effect of PFASs was positively associated with HDP. PFOS and PFBS showed positive trends, while PFHxS and PFHpA showed inverse trends. In WQS regression analysis, we calculated two WQS indices that were estimated using constraints in both the positive and negative directions of effects. Both WQS indices were significantly associated with HDP (OR: 2.663, 95% CI: 1.795–3.951; OR: 0.338, 95% CI: 0.229–0.499, respectively). PFBS, PFOS and PFUnA had significant weights in the positive effect direction; PFHxS, perfluoroheptanoic acid (PFHpA) and perfluorododecanoic acid (PFDoA) had significant weights in the negative effect direction. Conclusion: Considering all model results, we found that combined exposure to nine PFASs had a positive effect on the development of HDP. Moreover, PFOS and PFBS were positively associated with the HDP risk, while PFHxS and PFHpA were negatively associated with the HDP risk in women in Guangxi, China.

Hypertensive disorders of pregnancy Joint effect models Nested case-control study Perfluoroalkyl substances

SCI ; EI

英语

其他

WOS:000710183700006

20214110991908

High performance liquid chromatography ; Logistic regression ; Mass spectrometry ; Risk assessment

Medicine and Pharmacology:461.6 ; Chemistry:801 ; Accidents and Accident Prevention:914.1 ; Mathematical Statistics:922.2

ENVIRONMENT/ECOLOGY

2-s2.0-85116457183

Scopus

1.Department of Epidemiology and Health Statistics,School of Public Health,Guangxi Medical University,Nanning,530021,China
2.The Third Affiliated Hospital of Guangxi Medical University,Nanning,530031,China
3.Department of Toxicology,School of Public Health,Guangxi Medical University,Nanning,530021,China
4.Department of Epidemiology and Statistics,School of Public Health,Guilin Medical University,Guilin,541004,China
5.Department of Maternal,Child and Adolescent Health,School of Public Health,Guangxi Medical University,Nanning,530021,China
6.Department of Sanitary Chemistry,School of Public Health,Guangxi Medical University,Nanning,530021,China
7.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China

Liu，Bihu,Wei，Bincai,Mo，Meile,et al. Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China[J]. CHEMOSPHERE,2022,288.

Liu，Bihu.,Wei，Bincai.,Mo，Meile.,Song，Yanye.,Tang，Chuanqiao.,...&Qiu，Xiaoqiang.(2022).Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China.CHEMOSPHERE,288.

Liu，Bihu,et al."Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China".CHEMOSPHERE 288(2022).